Document Detail

Physiological consequences of testicular sperm extraction.
MedLine Citation:
PMID:  9308794     Owner:  NLM     Status:  MEDLINE    
Testicular sperm extraction (TESE) may provide spermatozoa for attempts at fertility with assisted reproduction; however, the physiological effects of TESE on testicular function are not well understood. In order to evaluate the effects of TESE on the testis, 64 patients were evaluated after TESE for non-obstructive azoospermia with physical examinations, serial scrotal sonography, histological analyses and evaluation of the success of repeated sperm retrieval attempts. At 3 months after TESE, 82% of evaluated patients had ultrasonographic abnormalities in the testis suggesting resolving inflammation or haematoma at the biopsy site. By 6 months, these acute inflammatory changes typically resolved leaving linear scars or calcifications. Two patients had documented impaired testicular blood flow, with complete devascularization of the testis for one patient after TESE with multiple biopsies. Repeat TESE procedures were far more likely to retrieve spermatozoa if the second TESE attempt was performed >6 months after the initial TESE procedure (80%), relative to those performed within 6 months (25%). Transient adverse physiological effects are common in the testis for up to 6 months after TESE. In addition, permanent devascularization of the testis can occur following TESE procedures with multiple biopsies. The risk of this complication may be minimized by using an open biopsy technique with optical magnification to directly identify testicular vessels.
P N Schlegel; L M Su
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  12     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-11-20     Completed Date:  1997-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1688-92     Citation Subset:  IM    
James Buchanan Brady Foundation, The Department of Urology, The New York Hospital-Cornell Medical Center, New York, NY 10021, USA.
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MeSH Terms
Cell Separation
Follow-Up Studies
Middle Aged
Oligospermia / pathology*
Regional Blood Flow
Spermatozoa / physiology*
Testis / blood supply,  cytology*,  ultrasonography
Ultrasonography, Doppler, Color
Comment In:
Hum Reprod. 1998 Feb;13(2):505-6   [PMID:  9557868 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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