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PHYSIOLOGICAL CONDITIONS EXISTING IN CONNECTIVE TISSUE : II. THE STATE OF THE FLUID IN THE INTRADERMAL TISSUE.
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MedLine Citation:
PMID:  19870846     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The interstitial movement of several dyes of widely different chemical constitution and diffusibility, in the connective tissues of the mouse ear, has been observed at high magnification. Dye extension seems to be conditioned by the form and structure of the connective tissue fibers. After escaping from the lymphatics of the ears of living mice, each dye appeared first in the tissues as bristly projections of color. These bent and twisted when pressed upon by a micro probe but sprang back into place when the pressure was removed. The present work and the preceding have shown that the lines of color are formed by dye along or between connective tissue fibers. Intermittent external pressure applied to the tissue, squeezes and bends the fibers together and greatly increases the spread of dye along them. The connective tissue fibers assume an important role in the spread of substances through tissues subjected to pressure changes. The experiments have given evidence of the existence of a tissue matrix in the organ but none of the presence of free interstitial fluid. In tissue subjected to irritant stimuli and in frankly edematous tissue, free fluid is readily demonstrated. When it is present the method of extension of dye is completely changed. Dye appears in the tissues as a diffusely colored cloud which can be freely moved by pressure with a micro probe. The bearing of this evidence upon the condition of interstitial fluid and the nature of the interstitial spaces is discussed.
Authors:
P D McMaster; R J Parsons
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  69     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1939 Jan 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-06-22     Revised Date:  2010-09-28    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-82     Citation Subset:  -    
Affiliation:
Laboratories of The Rockefeller Institute for Medical Research.
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Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1939, by The Rockefeller Institute for Medical Research New York
Received Day: 26 Month: 9 Year: 1938
Print publication date: Day: 31 Month: 1 Year: 1939
Volume: 69 Issue: 2
First Page: 265 Last Page: 282
ID: 2133738
PubMed Id: 19870846

PHYSIOLOGICAL CONDITIONS EXISTING IN CONNECTIVE TISSUE : II. THE STATE OF THE FLUID IN THE INTRADERMAL TISSUE
Philip D. McMaster
Robert J. Parsons
From the Laboratories of The Rockefeller Institute for Medical Research


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