Document Detail

Physiological comparison of three spontaneous breathing trials in difficult-to-wean patients.
MedLine Citation:
PMID:  20352189     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare cardiovascular and respiratory responses to different spontaneous breathing trials (SBT) in difficult-to-wean patients using T-piece and pressure support ventilation (PSV) with or without positive end-expiratory pressure (PEEP). METHODS: Prospective physiological study. Fourteen patients who were monitored with a Swan-Ganz catheter and had failed a previous T-piece trial were studied. Three SBTs were performed in random order in all patients: PSV with PEEP (PSV-PEEP), PSV without PEEP (PSV-ZEEP), and T-piece. PSV level was 7 cmH(2)O, and PEEP was 5 cmH(2)O. Inspiratory muscle effort was calculated, and hemodynamic parameters were measured using standard methods. RESULTS [MEDIAN (AND INTERQUARTILE RANGE)]: Most patients succeeded in the PSV-PEEP (11/14) and PSV-ZEEP (8/14) trials, but all failed the T-piece trial. Patient effort was significantly higher during T-piece than during PSV with or without PEEP [esophageal pressure-time product was 292 (238-512), 128 (58-299), and 148 (100-465) cmH(2)O x s/min, respectively, p < 0.05]. Left ventricular heart failure was observed in 11 of the 14 patients during the T-piece trial. Pulmonary artery occlusion pressure and respiratory rate were significantly higher during T-piece than with PSV-PEEP [21 (18-24) mmHg versus 17 (14-22) mmHg, p < 0.05 and 27 (21-35) breaths/min versus 19 (16-29) breaths/min, p < 0.05 respectively]. Tidal volume was significantly lower during the T-piece trial. CONCLUSION: In this selected population of difficult-to-wean patients, PSV and PSV plus PEEP markedly modified the breathing pattern, inspiratory muscle effort, and cardiovascular response as compared to the T-piece. Caregivers should be aware of these differences in SBT as they may play an important role in weaning decision-making.
Belén Cabello; Arnaud W Thille; Ferran Roche-Campo; Laurent Brochard; Francisco J Gómez; Jordi Mancebo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-30
Journal Detail:
Title:  Intensive care medicine     Volume:  36     ISSN:  1432-1238     ISO Abbreviation:  Intensive Care Med     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1171-9     Citation Subset:  IM    
Servei de Medicina Intensiva, Hospital Santa Creu i Sant Pau, C. Sant Quintí 89, 08041, Barcelona, Spain.
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MeSH Terms
Cardiac Output / physiology*
Catheterization, Swan-Ganz
Middle Aged
Monitoring, Physiologic / instrumentation,  methods
Positive-Pressure Respiration / instrumentation,  methods*
Prospective Studies
Respiratory Mechanics / physiology
Survival Analysis
Treatment Outcome
Ventilator Weaning / instrumentation,  methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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