| Physiological characterization and functional heterogeneity of narrow-field mammalian amacrine cells. | |
| | |
MedLine Citation:
|
PMID: 22083601 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Light-evoked responses of 106 morphologically-identified narrow-field amacrine cells (ACs) were studied in dark-adapted mouse retinal slices. 45 cells exhibit AIIAC morphology, 55% of which show characteristic AIIAC physiological properties (AIIACs) and the remaining 45% display different physiological responses, suggesting that AIIACs are functionally heterogeneous. Moreover, we found that 42 cells exhibit morphology that resembles the 7 morphological types of glycine-positive ACs (GlyAC1-7) reported in the rat retina, and for the first time assigned light response and function properties to these morphological types of glycinergic ACs in the mouse retina. In addition, 5 narrow-field ACs exhibited morphology resembling that of the GlyAC5 or GlyAC7 but with different physiological responses (GlyAC5# and GlyAC7#). Therefore, the 8 morphological types of narrow-field ACs exhibit 12 classes of physiological responses. Furthermore, we found ACs whose physiological responses are indistinguishable from those of GlyAC3 or GlyAC4s but with different morphology (GlyAC3*or GlyAC4*). These observations suggest that although the majority of narrow-field mammalian ACs forms discrete functional groups that correlate with their morphology, a significant number of these cells with similar morphology do not display the same light responses, and some with similar light responses do not exhibit the same morphology. |
| | |
Authors:
|
Ji-Jie Pang; Fan Gao; Samuel M Wu |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-14 |
Journal Detail:
|
Title: The Journal of physiology Volume: - ISSN: 1469-7793 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0266262 Medline TA: J Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Baylor College of Medicine. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lobule-specific membrane excitability of cerebellar Purkinje cells.
Next Document: Chronic imaging of cortical sensory map dynamics using a genetically encoded calcium indicator.