Document Detail

Physiological characteristics and hormonal profile of young normotensive men with exaggerated blood pressure response to exercise.
MedLine Citation:
PMID:  9015654     Owner:  NLM     Status:  MEDLINE    
Exaggerated blood pressure (BP) response to exercise in normotensive subjects is considered as a predictor of future hypertension. The aim of the study was to find out whether elevated BP response to exercise is associated with any other haemodynamic, metabolic or hormonal abnormalities. Abnormal BP response to exercise, i.e. systolic BP (SBP) > 200 mmHg at 150 W or lower workload, was found in 37 out of 180 normotensive, male students, aged 20-24 years. Fifteen students with elevated exercise BP (group E) volunteered for further examinations. Their resting and ambulatory BP showed high normal values. Eight of them had a family history of hypertension. Four subjects met the criteria of cardiac hypertrophy. Significant correlations were found between exercise SBP and left ventricular mass index, average 24 h and daytime SBP recordings. In comparison with normal subjects of the same age (group N, n = 13), those from group E did not differ in body mass index, plasma lipid profile, fasting glucose, insulin and catecholamine (CA) concentrations, but had increased erythrocyte sodium content, slightly elevated plasma renin activity and cortisol level. During exercise, E subjects showed greater cardiac output (CO) increases with normal heart rate, total peripheral resistance (TPR) and plasma CA. There were no significant differences between groups in haemodynamic and plasma CA responses to posture change from supine to standing. Glucose ingestion (75 g) caused smaller increases in CO and smaller decreases in TPR in E than in N subjects without differences in BP, blood glucose plasma insulin and CA. It is concluded that young normotensive men with exaggerated BP response to exercise show some other characteristics that may be considered as markers of predisposition to hypertension or factors promoting the development of hypertension.
K Nazar; H Kaciuba-Uscilko; W Ziemba; H Krysztofiak; E Wójcik-Ziólkowska; W Niewiadomski; J Chwalbinska-Moneta; B Bicz; E Stupnicka; A Okinczyc
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology (Oxford, England)     Volume:  17     ISSN:  0144-5979     ISO Abbreviation:  Clin Physiol     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-04     Completed Date:  1997-04-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8309768     Medline TA:  Clin Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-18     Citation Subset:  IM    
Department of Applied Physiology, Polish Academy of Sciences, Warsaw, Poland.
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MeSH Terms
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory
Body Mass Index
Catecholamines / blood
Exercise Test
Glucose Tolerance Test
Hemodynamics / physiology
Hydrocortisone / blood
Posture / physiology
Renin / metabolism
Reg. No./Substance:
0/Catecholamines; 50-23-7/Hydrocortisone; EC

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