| Physiological changes in pigs exposed to a blast wave from a detonating high-explosive charge. | |
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MedLine Citation:
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PMID: 10709373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this project was to study respiration, circulation, and brain activity in pigs during and after a blast wave exposure. Ten anesthetized pigs were used. Seven were exposed to blast and three were controls. Physiological parameters of respiration and circulation as well as cortical activity were followed from 30 minutes before until 120 minutes after the real or simulated blast. There were no significant changes in heart rhythm, cardiac output, arterial oxygen or carbon dioxide tension, blood pH, or mixed venous saturation during the experiment. The blast exposure caused intestinal injuries but no lung damage. A transient flattening of the electroencephalogram was seen immediately after the blast in four experimental animals, in contrast to the unchanged baseline electroencephalogram of the control animals. This momentary depression of cortical activity accompanied by short-lasting apnea indicates a blast wave-induced effect on the brainstem or higher controlling center. |
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Authors:
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H Axelsson; H Hjelmqvist; A Medin; J K Persson; A Suneson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Military medicine Volume: 165 ISSN: 0026-4075 ISO Abbreviation: Mil Med Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-03-29 Completed Date: 2000-03-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984771R Medline TA: Mil Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 119-26 Citation Subset: IM |
Affiliation:
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Weapons and Protection Division, Defense Research Establishment, Stockholm, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apnea / etiology*, metabolism, physiopathology Blast Injuries / complications, metabolism*, physiopathology* Blood Circulation / physiology* Blood Gas Analysis Brain / metabolism, physiopathology* Disease Models, Animal* Electroencephalography Explosions* Hemodynamics / physiology* Intestines / injuries Monitoring, Physiologic Postmortem Changes Respiratory Mechanics / physiology* Swine Time Factors Videotape Recording |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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