Document Detail

Physiological changes in pigs exposed to a blast wave from a detonating high-explosive charge.
MedLine Citation:
PMID:  10709373     Owner:  NLM     Status:  MEDLINE    
The aim of this project was to study respiration, circulation, and brain activity in pigs during and after a blast wave exposure. Ten anesthetized pigs were used. Seven were exposed to blast and three were controls. Physiological parameters of respiration and circulation as well as cortical activity were followed from 30 minutes before until 120 minutes after the real or simulated blast. There were no significant changes in heart rhythm, cardiac output, arterial oxygen or carbon dioxide tension, blood pH, or mixed venous saturation during the experiment. The blast exposure caused intestinal injuries but no lung damage. A transient flattening of the electroencephalogram was seen immediately after the blast in four experimental animals, in contrast to the unchanged baseline electroencephalogram of the control animals. This momentary depression of cortical activity accompanied by short-lasting apnea indicates a blast wave-induced effect on the brainstem or higher controlling center.
H Axelsson; H Hjelmqvist; A Medin; J K Persson; A Suneson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Military medicine     Volume:  165     ISSN:  0026-4075     ISO Abbreviation:  Mil Med     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-29     Completed Date:  2000-03-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2984771R     Medline TA:  Mil Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-26     Citation Subset:  IM    
Weapons and Protection Division, Defense Research Establishment, Stockholm, Sweden.
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MeSH Terms
Apnea / etiology*,  metabolism,  physiopathology
Blast Injuries / complications,  metabolism*,  physiopathology*
Blood Circulation / physiology*
Blood Gas Analysis
Brain / metabolism,  physiopathology*
Disease Models, Animal*
Hemodynamics / physiology*
Intestines / injuries
Monitoring, Physiologic
Postmortem Changes
Respiratory Mechanics / physiology*
Time Factors
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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