| Physiological and biochemical changes associated with macroconidial germination in Microsporum gypseum. | |
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MedLine Citation:
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PMID: 4650600 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study was made of the metabolic processes associated with macroconidial germination in Microsporum gypseum. The optimum conditions for stimulation of endogenous respiration, changes in chemical composition as germination proceeds, and the uptake and synthetic fates of amino acids, glucose, and uracil were investigated. The assimilation and conversion of (14)C-glucose, (14)C-amino acids, and (14)C-uracil into the cell pool and into trichloroacetic acid-precipitable material were studied during the early stages of germination (i.e., prior to germ-tube emergence). The macroconidia were not metabolically inert for any significant period of time after exposure to germination conditions. Rather, the spores rapidly assimilated all metabolites and slowly converted them into macromolecules. Investigations of the effect of inhibitors of nucleic acid and protein synthesis prior to germ-tube emergence and during early germ-tube elongation suggested significant changes in metabolism and cell permeability may be correlated with the emergence of germ tubes. Radioactivity of incorporated glucose was found to be associated largely with the lipid fractions of the macroconidia early in germination. |
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Authors:
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B C Dill; T J Leighton; J J Stock |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Applied microbiology Volume: 24 ISSN: 0003-6919 ISO Abbreviation: Appl Microbiol Publication Date: 1972 Dec |
Date Detail:
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Created Date: 1973-04-02 Completed Date: 1973-04-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7605802 Medline TA: Appl Microbiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 977-85 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism Carbon Isotopes Culture Media Cycloheximide / pharmacology DNA / biosynthesis Dactinomycin / pharmacology Fungal Proteins / biosynthesis Glucose / metabolism Manometry Microscopy, Interference Microsporum / cytology, growth & development*, metabolism Oxygen Consumption RNA / biosynthesis Spores / growth & development* Spores, Fungal / cytology, growth & development, metabolism Time Factors Uracil / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Carbon Isotopes; 0/Culture Media; 0/Fungal Proteins; 50-76-0/Dactinomycin; 50-99-7/Glucose; 63231-63-0/RNA; 66-22-8/Uracil; 66-81-9/Cycloheximide; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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