Document Detail

Physiological and biochemical changes associated with macroconidial germination in Microsporum gypseum.
MedLine Citation:
PMID:  4650600     Owner:  NLM     Status:  MEDLINE    
A study was made of the metabolic processes associated with macroconidial germination in Microsporum gypseum. The optimum conditions for stimulation of endogenous respiration, changes in chemical composition as germination proceeds, and the uptake and synthetic fates of amino acids, glucose, and uracil were investigated. The assimilation and conversion of (14)C-glucose, (14)C-amino acids, and (14)C-uracil into the cell pool and into trichloroacetic acid-precipitable material were studied during the early stages of germination (i.e., prior to germ-tube emergence). The macroconidia were not metabolically inert for any significant period of time after exposure to germination conditions. Rather, the spores rapidly assimilated all metabolites and slowly converted them into macromolecules. Investigations of the effect of inhibitors of nucleic acid and protein synthesis prior to germ-tube emergence and during early germ-tube elongation suggested significant changes in metabolism and cell permeability may be correlated with the emergence of germ tubes. Radioactivity of incorporated glucose was found to be associated largely with the lipid fractions of the macroconidia early in germination.
B C Dill; T J Leighton; J J Stock
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied microbiology     Volume:  24     ISSN:  0003-6919     ISO Abbreviation:  Appl Microbiol     Publication Date:  1972 Dec 
Date Detail:
Created Date:  1973-04-02     Completed Date:  1973-04-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7605802     Medline TA:  Appl Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  977-85     Citation Subset:  IM    
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MeSH Terms
Amino Acids / metabolism
Carbon Isotopes
Culture Media
Cycloheximide / pharmacology
DNA / biosynthesis
Dactinomycin / pharmacology
Fungal Proteins / biosynthesis
Glucose / metabolism
Microscopy, Interference
Microsporum / cytology,  growth & development*,  metabolism
Oxygen Consumption
RNA / biosynthesis
Spores / growth & development*
Spores, Fungal / cytology,  growth & development,  metabolism
Time Factors
Uracil / metabolism
Reg. No./Substance:
0/Amino Acids; 0/Carbon Isotopes; 0/Culture Media; 0/Fungal Proteins; 50-76-0/Dactinomycin; 50-99-7/Glucose; 63231-63-0/RNA; 66-22-8/Uracil; 66-81-9/Cycloheximide; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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