Document Detail


Physiological activation of plasminogen in full term newborn infants.
MedLine Citation:
PMID:  6542111     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasminogen in full term newborn infants has been measured by functional and immunological assays. Plasminogen functional activity and antigen concentration in newborn infants were about 44% and 48% of adult values respectively. Physiological activation kinetics of plasminogen in undiluted plasma at pH 7.4 and 37 degrees C using various concentrations of streptokinase and urokinase showed no significant difference in the rate of plasmin generation between plasminogen from newborn infants and adult plasminogen. These findings dispute the suggested existence of functional anomalies in plasminogen from full term newborn infants.
Authors:
M M Hilali; B E Gilliver
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  37     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-01-03     Completed Date:  1985-01-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1264-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Enzyme Activation
Humans
Infant, Newborn*
Kinetics
Plasminogen / analysis,  metabolism*
Plasminogen Activators / pharmacology
alpha-2-Antiplasmin / analysis
Chemical
Reg. No./Substance:
0/alpha-2-Antiplasmin; 9001-91-6/Plasminogen; EC 3.4.21.-/Plasminogen Activators
Comments/Corrections

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