Document Detail

Physiologic weight-bearing and consolidation of new bone in a rat model of distraction osteogenesis.
MedLine Citation:
PMID:  12198470     Owner:  NLM     Status:  MEDLINE    
To evaluate the effect of weight-bearing on consolidation of the regenerate in distraction osteogenesis, unilateral femoral lengthenings were performed in two groups of rats. In the first group (n = 19) unrestricted weight-bearing was permitted postoperatively, while in the second (n = 18) weight-bearing was prevented via a through-knee amputation. In both groups the distraction protocol involved a 3-day latency period, four daily 0.5-mm lengthenings, and 35 days of consolidation. Healing was evaluated with serial radiographs (days 0, 7, 14, 28, and 35) and at sacrifice with measurement of ash weight, quantitative histology, and mechanical testing. Histomorphometry revealed that the callus in the weight-bearing animals was significantly larger than in the non-weight-bearing animals, primarily due to increases in periosteal and interzone new bone; there was no significant increase in cartilage formation. Weight-bearing had no significant effect on the stiffness, strength, or mineral content of the regenerate. These findings suggest that weight-bearing may be capable of influencing consolidation of the regenerate in distraction osteogenesis. Additional studies will be required to determine the optimal loading for new bone formation.
Donna M Pacicca; Douglas C Moore; Michael G Ehrlich
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric orthopedics     Volume:  22     ISSN:  0271-6798     ISO Abbreviation:  J Pediatr Orthop     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2002-08-28     Completed Date:  2002-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109053     Medline TA:  J Pediatr Orthop     Country:  United States    
Other Details:
Languages:  eng     Pagination:  652-9     Citation Subset:  IM    
Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts 02903, USA.
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MeSH Terms
Bone Density
Models, Animal
Osteogenesis, Distraction*
Random Allocation
Rats, Sprague-Dawley

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