| Physiologic variations in granulocytic surface antigen expression: impact of age, gender, pregnancy, race, and stress. | |
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MedLine Citation:
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PMID: 14557386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is a growing interest in the use of granulocytic surface markers for the diagnosis of some inherited and acquired disorders, such as Shwachman-Diamond syndrome and myelodysplastic syndromes. Understanding the impact of physiologic factors, such as age, gender, pregnancy, race, and stress on granulocytic surface markers is essential for appropriate interpretation of results. Some surface markers show marked variations at the very early and the very late stages in life. Fetal granulocytes tend to have a lower expression of CD11b, CD11c, CD18, and CD32. Term neonatal granulocytes are frequently associated with a lower expression of CD10, CD11b, CD13, CD33, and CD62L and a higher expression of CD55 and CD64. Elderly individuals have shown a higher expression of CD64. Pregnancy is associated with temporary changes in granulocytic surface markers, such as a lower expression of CD16 and a higher CD64, partially mimicking an inflammatory response. Stress also has an impact on some surface markers, particularly adhesion molecules, such as CD62L and CD54. These factors need to be taken in consideration for the optimal interpretation of granulocytic surface marker studies. |
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Authors:
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M Tarek Elghetany; Francis Lacombe |
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Publication Detail:
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Type: Journal Article; Review Date: 2003-10-13 |
Journal Detail:
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Title: Journal of leukocyte biology Volume: 75 ISSN: 0741-5400 ISO Abbreviation: J. Leukoc. Biol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-02-05 Completed Date: 2004-03-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 157-62 Citation Subset: IM |
Affiliation:
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University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0743, USA. melgheta@utmb.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Antigens, CD Antigens, Surface* Continental Population Groups Female Granulocytes / immunology, metabolism* Humans Male Pregnancy Sex Factors Stress, Physiological |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Surface |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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