Document Detail

Physiologic role of somatostatin. Insulin release from rat islets treated by somatostatin antiserum.
MedLine Citation:
PMID:  326606     Owner:  NLM     Status:  MEDLINE    
In order to clarify the physiologic role of somatostatin in insulin release, rat pancreatic islets treated by somatostatin antiserum were incubated in media containing various concentrations of glucose. Insulin release from antiserum-treated islets was significantly elevated above that from nontreated ones at 3.3 and 8.3 mM glucose, while the former was not different from the latter at 16.7 mM glucose. It is suggested that somatostatin plays an important role in the regulation of insulin release in the physiologic range of glucose concentration.
H Taniguchi; M Utsumi; M Hasegawa; T Kobayashi; Y Watanabe; K Murakami; M Seki; A Tsutou; H Makimura; M Sakoda; S Baba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes     Volume:  26     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-09-02     Completed Date:  1977-09-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  700-2     Citation Subset:  AIM; IM    
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MeSH Terms
Dose-Response Relationship, Drug
Glucose / pharmacology
Immune Sera / pharmacology*
Insulin / secretion*
Islets of Langerhans / drug effects,  secretion*
Somatostatin / immunology,  physiology*
Reg. No./Substance:
0/Immune Sera; 11061-68-0/Insulin; 50-99-7/Glucose; 51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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