Document Detail

Physiologic estradiol replacement therapy and cardiac structure and function in normal postmenopausal women: a randomized, double-blind, placebo-controlled, crossover trial.
MedLine Citation:
PMID:  9052580     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effect of estradiol (E2) replacement therapy on cardiac structure and function in healthy postmenopausal women. METHODS: We conducted a randomized, double-blind, placebo-controlled, crossover study of 31 healthy postmenopausal female volunteer study subjects (55-65 years) using 12 weeks of micronized E2 replacement therapy (2 mg/day). Echocardiography and Doppler techniques were used to assess the cardiac effects of E2 at rest and during graded bicycle ergometry. RESULTS: Crossover analysis demonstrated no carryover effects of estrogen treatment (which increased serum E2 15-fold to 37.6 pmol/L) on the cardiac characteristics measured. Estradiol treatment did not affect measurements of systolic function, diastolic function, left ventricular mass, or pulmonary artery pressure at rest or during bicycle ergometry. Left ventricular end-diastolic volume at rest was slightly higher with E2 treatment (P = .03). However, this change was not reflected by changes in stroke volume, ejection fraction, or cardiac output. CONCLUSIONS: Estrogen replacement therapy, which results in physiologic serum concentrations, does not affect cardiac structure or function in normal postmenopausal women after 12 weeks of treatment.
M C Snabes; J P Payne; H A Kopelen; J K Dunn; R L Young; W A Zoghbi
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  89     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-03-20     Completed Date:  1997-03-20     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  332-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
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MeSH Terms
Cross-Over Studies
Estradiol / pharmacology*
Estrogen Replacement Therapy*
Heart Ventricles / anatomy & histology*,  drug effects*
Middle Aged
Myocardial Contraction / drug effects*,  physiology*
Reg. No./Substance:

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