Document Detail

Physiologic effects of cisapride on gastric emptying after pylorus-preserving gastrectomy for early gastric cancer.
MedLine Citation:
PMID:  9465759     Owner:  NLM     Status:  MEDLINE    
Pylorus-preserving gastrectomy (PPG) has been considered reasonable reduction surgery. However, even patients in whom more than 1 year passed after surgery frequently have a feeling of gastric fullness after meals and long-term retention of foods in the residual stomach. To treat this syndrome, cisapride has been administered. We studied the emptying time of a semisolid diet (radioisotope method using 99mTc-tin colloid-labeled rice gruel) and the emptying time of a fluid diet (acetaminophen method with orange juice) before and after oral administration of cisapride (15 mg/day for 1 month) in 14 patients (10 men, 4 women; 32-70 years old, average 60.6 years) who underwent PPG (Billroth I procedure, D2 lymph node dissection, curability A) for treatment of early gastric cancer. Ten healthy volunteers without gastrointestinal symptoms and digestive diseases (7 men, 3 women; 28-61 years old, average 49.8 years) were enrolled as controls. The results showed obviously delayed emptying time of the semisolid diet before administration of cisapride in patients with PPG compared with that of the control group, whereas the emptying curves for the fluid diet showed an almost normal pattern. One month after the start of cisapride administration the emptying time of the semisolid diet was improved, and the emptying curves were close to the patterns in the control group. Emptying of the fluid diet was slightly accelerated compared with that before administration of cisapride, and the emptying curves showed almost the same pattern as in the control group. A postgastrectomy symptom, "gastric fullness," after PPG was alleviated by cisapride. These results showed that cisapride improved delayed emptying of a semisolid diet after PPG and prevented the feeling of gastric fullness after meals due to retention in the residual stomach.
R Tomita; H Takizawa; K Tanjoh
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  World journal of surgery     Volume:  22     ISSN:  0364-2313     ISO Abbreviation:  World J Surg     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-03     Completed Date:  1998-04-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-40; discussion 40-1     Citation Subset:  IM    
Department of First Surgery, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Gastric Emptying / drug effects*
Gastrointestinal Agents / pharmacology*
Middle Aged
Piperidines / pharmacology*
Stomach Neoplasms / surgery*
Reg. No./Substance:
0/Gastrointestinal Agents; 0/Piperidines; 81098-60-4/Cisapride

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