Document Detail


Physiologic brain dysmaturity in late preterm infants.
MedLine Citation:
PMID:  21796018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal EEG sleep was used to determine whether differences are expressed between healthy late preterm and full-term (FT) groups. Twenty-seven 24-channel multihour studies were recorded at similar postmenstrual ages (PMA) and analyzed for eight asymptomatic late preterm infants (LPT) compared with 19 healthy FT infants as a preliminary analysis, followed by a comparison of a subset of eight FT infants, matched for gender, race, and PMA. Z scores were performed on data sets from each group pair comparing each of seven EEG/Sleep measures for entire recordings, active sleep (AS) and quiet sleep (QS) segments and artifact-free intervals. Six of seven measures showed differences between the eight LPT and eight matched FT cohort pair comparisons of >0.3; rapid eye movements, arousals during QS, spectral correlations between homologous centrotemporal regions during QS, spectral beta/alpha power ratios during AS and QS, a spectral measure of respiratory regularity during QS, and sleep cycle length. Quantitative neurophysiologic analyses define differences in brain maturation between LPT and FT infants at similar PMA. Altered EEG/Sleep behaviors in the LPT are biomarkers of developmental neuroplasticity involving interconnected neuronal networks adapting to conditions of prematurity for this largest segment of the preterm neonatal population.
Authors:
Mark S Scher; Mark W Johnson; Susan M Ludington; Kenneth Loparo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric research     Volume:  70     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-07     Completed Date:  2012-02-07     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  524-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Brain / growth & development*
Brain Waves / physiology*
Electroencephalography
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature / physiology*
Male
Respiration
Sleep / physiology*
Grant Support
ID/Acronym/Agency:
NR 04926/NR/NINR NIH HHS; NR01894/NR/NINR NIH HHS; NS26793/NS/NINDS NIH HHS; NS34508/NS/NINDS NIH HHS; R01 NS034508/NS/NINDS NIH HHS; R01 NS034508-04/NS/NINDS NIH HHS; RR 00084/RR/NCRR NIH HHS
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