| Physiologic brain dysmaturity in late preterm infants. | |
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MedLine Citation:
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PMID: 21796018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonatal EEG sleep was used to determine whether differences are expressed between healthy late preterm and full-term (FT) groups. Twenty-seven 24-channel multihour studies were recorded at similar postmenstrual ages (PMA) and analyzed for eight asymptomatic late preterm infants (LPT) compared with 19 healthy FT infants as a preliminary analysis, followed by a comparison of a subset of eight FT infants, matched for gender, race, and PMA. Z scores were performed on data sets from each group pair comparing each of seven EEG/Sleep measures for entire recordings, active sleep (AS) and quiet sleep (QS) segments and artifact-free intervals. Six of seven measures showed differences between the eight LPT and eight matched FT cohort pair comparisons of >0.3; rapid eye movements, arousals during QS, spectral correlations between homologous centrotemporal regions during QS, spectral beta/alpha power ratios during AS and QS, a spectral measure of respiratory regularity during QS, and sleep cycle length. Quantitative neurophysiologic analyses define differences in brain maturation between LPT and FT infants at similar PMA. Altered EEG/Sleep behaviors in the LPT are biomarkers of developmental neuroplasticity involving interconnected neuronal networks adapting to conditions of prematurity for this largest segment of the preterm neonatal population. |
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Authors:
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Mark S Scher; Mark W Johnson; Susan M Ludington; Kenneth Loparo |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Pediatric research Volume: 70 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-07 Completed Date: 2012-02-07 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 524-8 Citation Subset: IM |
Affiliation:
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Department of Pediatric Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. mark.scher@uhhospitals.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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growth & development* Brain Waves / physiology* Electroencephalography Female Gestational Age Humans Infant, Newborn Infant, Premature / physiology* Male Respiration Sleep / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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NR 04926/NR/NINR NIH HHS; NR01894/NR/NINR NIH HHS; NS26793/NS/NINDS NIH HHS; NS34508/NS/NINDS NIH HHS; R01 NS034508-04/NS/NINDS NIH HHS; RR 00084/RR/NCRR NIH HHS |
| Comments/Corrections | |
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