Document Detail

Physiologic basis for understanding quantitative dehydration assessment.
MedLine Citation:
PMID:  23343973     Owner:  NLM     Status:  MEDLINE    
Dehydration (body water deficit) is a physiologic state that can have profound implications for human health and performance. Unfortunately, dehydration can be difficult to assess, and there is no single, universal gold standard for decision making. In this article, we review the physiologic basis for understanding quantitative dehydration assessment. We highlight how phenomenologic interpretations of dehydration depend critically on the type (dehydration compared with volume depletion) and magnitude (moderate compared with severe) of dehydration, which in turn influence the osmotic (plasma osmolality) and blood volume-dependent compensatory thresholds for antidiuretic and thirst responses. In particular, we review new findings regarding the biological variation in osmotic responses to dehydration and discuss how this variation can help provide a quantitative and clinically relevant link between the physiology and phenomenology of dehydration. Practical measures with empirical thresholds are provided as a starting point for improving the practice of dehydration assessment.
Samuel N Cheuvront; Robert W Kenefick; Nisha Charkoudian; Michael N Sawka
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-23
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  97     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-21     Completed Date:  2013-04-15     Revised Date:  2013-09-11    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  455-62     Citation Subset:  AIM; IM    
US Army Research Institute of Environmental Medicine, Natick, MA, USA.
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MeSH Terms
Blood Volume / physiology
Body Water / physiology
Neurophysins / metabolism
Osmolar Concentration
Protein Precursors / metabolism
Thirst / physiology
Vasopressins / metabolism
Water-Electrolyte Balance
Reg. No./Substance:
0/AVP protein, human; 0/Neurophysins; 0/Protein Precursors; 11000-17-2/Vasopressins
Comment In:
Am J Clin Nutr. 2013 Aug;98(2):505-6
Am J Clin Nutr. 2013 Aug;98(2):503-4   [PMID:  23873679 ]

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