Document Detail

Physiologic basis for the surgical treatment of ischemic mitral regurgitation.
MedLine Citation:
PMID:  17086006     Owner:  NLM     Status:  MEDLINE    
Ischemic mitral regurgitation (MR) can complicate severe coronary artery disease and myocardial infarction. Ischemic MR results from left ventricular remodeling after myocardial infarction and can also accompany acute myocardial ischemia. The most common mechanism of ischemic MR is Carpentier's type IIIb dysfunction due to an apical and lateral displacement of papillary muscles leading to a tethering of the mitral leaflets. This apical tenting of the leaflets prevents the free margin from reaching the plane of the annulus, significantly reduces the surface of coaptation, and causes MR. Recent advances in imaging studies have led to a better understanding of the pathophysiology of this condition as well as to the development of innovative surgical approaches to treat this disease. Current research efforts have mainly focused on 2 directions: (1) percutaneous approaches to correct MR, and (2) surgical therapy to address the ventricular component of the disease. In this article, the authors define ischemic MR and review its pathophysiology, current management strategies, and future directions.
Farzan Filsoufi; Parwis B Rahmanian; Anelechi Anyanwu; David H Adams
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American heart hospital journal     Volume:  4     ISSN:  1541-9215     ISO Abbreviation:  Am Heart Hosp J     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-06     Completed Date:  2007-05-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101156064     Medline TA:  Am Heart Hosp J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-8     Citation Subset:  IM    
Department of Cardiothoracic Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA.
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MeSH Terms
Clinical Trials as Topic
Coronary Artery Bypass*
Coronary Artery Disease / complications*,  physiopathology,  surgery*
Heart Valve Prosthesis Implantation*
Mitral Valve Insufficiency / etiology,  physiopathology*,  surgery*
Myocardial Infarction / complications,  surgery
Ventricular Dysfunction, Left / complications,  surgery
Ventricular Remodeling

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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