Document Detail

Physiologic basis for BOLD MR signal changes due to hypoxia/hyperoxia: separation of blood volume and magnetic susceptibility effects.
MedLine Citation:
PMID:  9178248     Owner:  NLM     Status:  MEDLINE    
An NMR method is presented for separating blood volume and magnetic susceptibility effects in response to respiratory challenges such as hypoxia and hyperoxia. The technique employs high susceptibility contrast agents to enhance blood volume induced signal changes. The results show that for a rat model the dominant source of signal variation upon changing breathing gas from 100% oxygen to 10% oxygen/90% nitrogen is the change in blood magnetic susceptibility associated with the BOLD effect. The results imply that signal changes associated with respiratory challenges can be regarded as indicators of local blood oxygenation in vivo.
R P Kennan; B E Scanley; J C Gore
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  37     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-06     Completed Date:  1997-08-06     Revised Date:  2009-12-02    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  953-6     Citation Subset:  IM; S    
Department of Diagnostic Radiology, Yale University School of Medicine, West Haven VAMC, Connecticut, USA.
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MeSH Terms
Anoxia / physiopathology*
Blood Volume*
Brain / metabolism
Cerebrovascular Circulation*
Contrast Media
Ferrosoferric Oxide
Hyperoxia / physiopathology*
Iron / diagnostic use
Magnetic Resonance Spectroscopy*
Oxides / diagnostic use
Oxygen / blood
Rats, Sprague-Dawley
Reg. No./Substance:
0/Contrast Media; 0/Oxides; 0/ferumoxtran-10; 1317-61-9/Ferrosoferric Oxide; 7439-89-6/Iron; 7782-44-7/Oxygen; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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