| Physiologic basis for BOLD MR signal changes due to hypoxia/hyperoxia: separation of blood volume and magnetic susceptibility effects. | |
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MedLine Citation:
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PMID: 9178248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An NMR method is presented for separating blood volume and magnetic susceptibility effects in response to respiratory challenges such as hypoxia and hyperoxia. The technique employs high susceptibility contrast agents to enhance blood volume induced signal changes. The results show that for a rat model the dominant source of signal variation upon changing breathing gas from 100% oxygen to 10% oxygen/90% nitrogen is the change in blood magnetic susceptibility associated with the BOLD effect. The results imply that signal changes associated with respiratory challenges can be regarded as indicators of local blood oxygenation in vivo. |
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Authors:
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R P Kennan; B E Scanley; J C Gore |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 37 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-08-06 Completed Date: 1997-08-06 Revised Date: 2009-12-02 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 953-6 Citation Subset: IM; S |
Affiliation:
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Department of Diagnostic Radiology, Yale University School of Medicine, West Haven VAMC, Connecticut, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / physiopathology* Blood Volume* Brain / metabolism Cerebrovascular Circulation* Contrast Media Dextrans Ferrosoferric Oxide Hyperoxia / physiopathology* Iron / diagnostic use Magnetic Resonance Spectroscopy* Oxides / diagnostic use Oxygen / blood Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Oxides; 0/ferumoxtran-10; 1317-61-9/Ferrosoferric Oxide; 7439-89-6/Iron; 7782-44-7/Oxygen; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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