Document Detail

Physiochemical properties and prolonged release behaviours of chitosan-denatured β-lactoglobulin microcapsules for potential food applications.
MedLine Citation:
PMID:  23107718     Owner:  NLM     Status:  In-Data-Review    
Chitosan (CS) and β-lactoglobulin (βlg) double-wall coating was designed as a shell structure to achieve prolonged release of core material in the gastrointestinal tract (GI) for potential food applications. A model core material, brilliant blue (BB) dye, was incorporated into CS as the primary wall material, and subsequently, denatured βlg, a secondary wall material, was used to coat the outer layer. The strongest interaction occurred between 0.5% (w/v) βlg and 0.5% (w/v) CS at pH 5.5±0.1, where the opposite charges of CS and βlg formed a complex, which is especially favourable in acidic beverage systems. Under simulated stomach conditions, a denatured-βlg coat resisted acid conditions and pepsin hydrolysis for 2h. While mimicking small intestine conditions, βlg was degraded by pancreatin, causing the release of BB-loaded CS to the intestinal fluid at a constant rate. The sustained release of core material later in the GI tract provided an optimal absorption rate in the small intestine.
Pei Sia Lee; Sun Goo Yim; Yeri Choi; Thi Van Anh Ha; Sanghoon Ko
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Publication Detail:
Type:  Journal Article     Date:  2012-03-07
Journal Detail:
Title:  Food chemistry     Volume:  134     ISSN:  0308-8146     ISO Abbreviation:  Food Chem     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702639     Medline TA:  Food Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  992-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Food Science and Technology, Sejong University, 98 Gunja-dong, Gwangjin gu, Seoul 143-747, Republic of Korea.
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