Document Detail


Physics of bacterial morphogenesis.
MedLine Citation:
PMID:  22126993     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bacterial cells utilize three-dimensional (3D) protein assemblies to perform important cellular functions such as growth, division, chemoreception, and motility. These assemblies are composed of mechanoproteins that can mechanically deform and exert force. Sometimes, small-nucleotide hydrolysis is coupled to mechanical deformations. In this review, we describe the general principle for an understanding of the coupling of mechanics with chemistry in mechanochemical systems. We apply this principle to understand bacterial cell shape and morphogenesis and how mechanical forces can influence peptidoglycan cell wall growth. We review a model that can potentially reconcile the growth dynamics of the cell wall with the role of cytoskeletal proteins such as MreB and crescentin. We also review the application of mechanochemical principles to understand the assembly and constriction of the FtsZ ring. A number of potential mechanisms are proposed, and important questions are discussed.
Authors:
Sean X Sun; Hongyuan Jiang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Microbiology and molecular biology reviews : MMBR     Volume:  75     ISSN:  1098-5557     ISO Abbreviation:  Microbiol. Mol. Biol. Rev.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-30     Completed Date:  2012-04-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9706653     Medline TA:  Microbiol Mol Biol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  543-65     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, Whitaker Institute of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. ssun@jhu.edu
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MeSH Terms
Descriptor/Qualifier:
Bacteria / cytology,  growth & development*,  metabolism
Bacterial Proteins / chemistry,  metabolism
Biomechanics
Cell Division / physiology
Cell Wall / chemistry,  metabolism
Cytoskeletal Proteins / chemistry,  metabolism
Molecular Dynamics Simulation
Morphogenesis*
Grant Support
ID/Acronym/Agency:
GM075305/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Cytoskeletal Proteins
Comments/Corrections
Erratum In:
Microbiol Mol Biol Rev. 2012 Mar;76(1):113

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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