| Physics of bacterial morphogenesis. | |
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MedLine Citation:
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PMID: 22126993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bacterial cells utilize three-dimensional (3D) protein assemblies to perform important cellular functions such as growth, division, chemoreception, and motility. These assemblies are composed of mechanoproteins that can mechanically deform and exert force. Sometimes, small-nucleotide hydrolysis is coupled to mechanical deformations. In this review, we describe the general principle for an understanding of the coupling of mechanics with chemistry in mechanochemical systems. We apply this principle to understand bacterial cell shape and morphogenesis and how mechanical forces can influence peptidoglycan cell wall growth. We review a model that can potentially reconcile the growth dynamics of the cell wall with the role of cytoskeletal proteins such as MreB and crescentin. We also review the application of mechanochemical principles to understand the assembly and constriction of the FtsZ ring. A number of potential mechanisms are proposed, and important questions are discussed. |
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Authors:
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Sean X Sun; Hongyuan Jiang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Microbiology and molecular biology reviews : MMBR Volume: 75 ISSN: 1098-5557 ISO Abbreviation: Microbiol. Mol. Biol. Rev. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-30 Completed Date: 2012-04-23 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 9706653 Medline TA: Microbiol Mol Biol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 543-65 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, Whitaker Institute of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. ssun@jhu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacteria
/
cytology,
growth & development*,
metabolism Bacterial Proteins / chemistry, metabolism Biomechanics Cell Division / physiology Cell Wall / chemistry, metabolism Cytoskeletal Proteins / chemistry, metabolism Molecular Dynamics Simulation Morphogenesis* |
| Grant Support | |
ID/Acronym/Agency:
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GM075305/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Cytoskeletal Proteins |
| Comments/Corrections | |
Erratum In:
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Microbiol Mol Biol Rev. 2012 Mar;76(1):113 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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