Document Detail


Physicomechanical characterization of the extrusion-spheronization process. I. Instrumentation of the extruder.
MedLine Citation:
PMID:  8008698     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Extrusion-spheronization is a popular means of producing spheres which can be coated to form a controlled-release system. In the extrusion process, stress is necessary to force a wet mass through small orifices, and as a result, frictional heat builds up at the screen. Therefore, the quantitative measurement of the screen pressure and screen temperature is described and shown to provide objective measures of extrudability. A strain gauge load cell was mounted tangentially to the screen of a Luwa EXDS-60 extruder with a specifically fabricated holder. The load cell output was calibrated in terms of pressure inside the screen with a special rubber plug system. A fast-response thermocouple was used to measure the screen temperature. Experiments with 50/50 lactose/Avicel PH101 revealed that a linear relationship exists between the amount of water used in the granulation and the screen pressure, that the percentage open area of the screen determines the rank order of the screen pressure, and that the maximal yield of 18/25-mesh cut pellets was uniquely related to the screen pressure. Also, a high degree of correlation was observed between the screen pressure and the screen temperature.
Authors:
R D Shah; M Kabadi; D G Pope; L L Augsburger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmaceutical research     Volume:  11     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-19     Completed Date:  1994-07-19     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  355-60     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, University of Maryland, Baltimore 21201.
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MeSH Terms
Descriptor/Qualifier:
Drug Compounding / instrumentation*
Microspheres*
Particle Size
Pressure
Temperature
Water
Chemical
Reg. No./Substance:
7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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