Document Detail


Physicochemical studies of binary eutectic of ibuprofen and ketoprofen for enhanced transdermal drug delivery.
MedLine Citation:
PMID:  20367290     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
METHODS: The thermodynamic, eutectic, and crystalline properties of ibuprofen and ketoprofen binary mixtures were investigated using differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRPD).
RESULTS: The DSC studies showed that melting point (61 degrees C), enthalpy (11.3 kJ/mol), and entropy of fusion (33.7 J/K/mol) of the binary eutectic were significantly lower than those of the individual anti-inflammatory drugs (NSAIDs). Due to the melting-point depression and enhanced skin lipid solubility, the steady-state flux of ibuprofen and ketoprofen from preparations of the binary eutectic increased as compared to pure NSAIDs using shed snakeskin as a model membrane. The NSAID membrane flux values were calculated by flux ratio equations based on drug thermodynamic data, and compared to experimental values obtained from permeation studies.
CONCLUSION: The proposed flux ratio equations correctly predicted flux increase.
Authors:
Xudong Yuan; Anthony Cesare Capomacchia
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  36     ISSN:  1520-5762     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  England    
Other Details:
Languages:  eng     Pagination:  1168-76     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, USA.
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