Document Detail


Physicochemical property trends of marketed prodrugs.
MedLine Citation:
PMID:  23343161     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Many prodrug reviews describe specific examples of the successful application of prodrug technology to produce blockbuster drugs, such as simvastatin, omeprazole, acyclovir and enalapril. These reviews are helpful to understand the previous success stories and case histories of prodrug technology. The aim of the current review seeks to more clearly define quantitative trends in the changes in the physicochemical property parameters between the successful prodrug and the active parent molecule. This information can serve to guide medicinal chemists toward more successful pharmaceutical prodrugs in the future.
Authors:
Margaret S Landis
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic delivery     Volume:  4     ISSN:  2041-5990     ISO Abbreviation:  Ther Deliv     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101538870     Medline TA:  Ther Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  225-37     Citation Subset:  IM    
Affiliation:
Pfizer Global Research & Development, Pharmaceutical Sciences-Research Formulations, Eastern Point Road, Groton, CT 06340, USA. margaret.s.landis@pfizer.com.
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