Document Detail


Physicochemical properties of ferumoxytol, a new intravenous iron preparation.
MedLine Citation:
PMID:  19397688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Intravenous iron is a critical component of anaemia management. However, currently available preparations have been associated with the release of free iron, a promoter of bacterial growth and oxidative stress. MATERIALS AND METHODS: We determined the molecular weight, dialysability and capacity for free iron release of ferumoxytol, a semi-synthetic carbohydrate-coated superparamagnetic iron oxide nanoparticle. Ferumoxytol was compared with three intravenous iron preparations in clinical use: iron dextran (low molecular weight), sodium ferric gluconate and iron sucrose. Intravenous iron preparations were also incubated in rat, and pooled human sera (at concentrations of 600 microM and 42 microg mL(-1) respectively) from healthy subjects. RESULTS: The molecular weight of ferumoxytol was 731 kDa. The relative order of molecular weight was as follows: ferumoxytol > iron dextran > iron sucrose > sodium ferric gluconate. The least ultrafilterable iron was observed with ferumoxytol and the most with ferric gluconate. The least dialysable free iron was observed with ferumoxytol and the most with ferric gluconate. Incubation of intravenous iron preparations in rat or pooled human sera demonstrated minimal free iron release with ferumoxytol. The order of catalytic iron release as detected by the bleomycin detectable iron assay was as follows: ferumoxytol < iron dextran < iron sucrose < ferric gluconate. A similar trend was observed for the in vivo serum concentration of free iron in rats. CONCLUSIONS: In vitro observations from these experiments suggest that ferumoxytol has a favourable profile in terms of tendency to release free iron, in comparison with currently available intravenous iron preparations.
Authors:
V S Balakrishnan; M Rao; A T Kausz; L Brenner; B J G Pereira; T B Frigo; J M Lewis
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Publication Detail:
Type:  Journal Article     Date:  2009-04-23
Journal Detail:
Title:  European journal of clinical investigation     Volume:  39     ISSN:  1365-2362     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-03     Completed Date:  2009-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  489-96     Citation Subset:  IM    
Affiliation:
Tufts Medical Center, Boston, MA, USA. vbalakrishnan@tuftsmedicalcenter.org
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MeSH Terms
Descriptor/Qualifier:
Anemia / blood,  drug therapy*
Animals
Drug Administration Schedule
Ferrosoferric Oxide / pharmacology*,  therapeutic use
Humans
Infusions, Intravenous
Iron-Dextran Complex / pharmacology*
Kidney Failure, Chronic / blood,  drug therapy*
Molecular Weight
Oxidative Stress / drug effects*
Rats
Chemical
Reg. No./Substance:
1317-61-9/Ferrosoferric Oxide; 9004-66-4/Iron-Dextran Complex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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