Document Detail

Physicochemical properties and biocompatibility of N-trimethyl chitosan: effect of quaternization and dimethylation.
MedLine Citation:
PMID:  18602467     Owner:  NLM     Status:  MEDLINE    
The aim of this research was to investigate the effect of degrees of quaternization (DQ) and dimethylation (DD) on physicochemical properties and cytotoxicity of N-trimethyl chitosan (TMC). TMC was synthesized by reductive methylation of chitosan in the presence of a strong base at elevated temperature and polymer characteristics were investigated. The number of methylation process and duration of reaction were demonstrated to affect the DQ and DD. An increased number of reaction steps increased DQ and decreased DD, while an extended duration of reaction increased both DQ and DD. The molecular weight of TMC was in the range of 60-550kDa. From the Mark-Houwink equation, it was found that TMC in 2% acetic acid/0.2M sodium acetate behaved as a spherical structure, approximating a random coil. The highest solubility was found with TMC of an intermediate DQ (40%) regardless of DD and molecular weight. The effect of DD on the physicochemical properties and cytotoxicity was obviously observed when proportion of DD to DQ was higher than 1. TMC with relatively high DD showed reduction in both solubility and mucoadhesion and hence decreased cytotoxicity. However, the influence of DD was insignificant when DQ of TMC was higher than 40% at which physicochemical properties and cytotoxicity were mainly dependent upon DQ.
Anchalee Jintapattanakit; Shirui Mao; Thomas Kissel; Varaporn Buraphacheep Junyaprasert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-17
Journal Detail:
Title:  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V     Volume:  70     ISSN:  0939-6411     ISO Abbreviation:  Eur J Pharm Biopharm     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2008-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109778     Medline TA:  Eur J Pharm Biopharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  563-71     Citation Subset:  IM    
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Cell Line
Cell Survival / drug effects
Chitosan / chemistry*,  pharmacology
Drug Carriers / chemistry*
Materials Testing
Molecular Weight
Osmolar Concentration
Reg. No./Substance:
0/Drug Carriers; 0/N-trimethyl chitosan chloride; 9012-76-4/Chitosan

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