Document Detail


Physico-Chemical Characterization of γ-Amino n-Butyric Acid Nanoparticles.
MedLine Citation:
PMID:  21628904     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This work deals with the preparation and characterization of high-purity nanoparticles of γ-amino n-butyric acid (GABA) in order to enhance the efficiency of this drug. A sublimation procedure at low pressure was applied to GABA after improving the experimental parameters of this physical transformation. The elaboration of the molecule is solvent-free. The process does not change the chemical formula of the compound but modifies its physico-chemical characteristics. In this work, we present the experimental parameters for preparing monoclinic GABA nanoparticles. Their identification and physico-chemical properties were determined with a large number of investigations: Powder X-ray diffraction (PXRD), density and purity measurements, differential scanning calorimetry (DSC), thermo-gravimetric analysis (TGA), calorimetric measurements (ΔH(dissolution) and C(p)), thermally stimulated current (TSC), and electrochemical impedance.
Authors:
Emma Dichi; Mehrez Sghaier; Bernard Fraisse; François Bonhomme
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  59     ISSN:  1347-5223     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  703-9     Citation Subset:  IM    
Affiliation:
Matériaux et Santé, EA 401 Faculté de Pharmacie, Université Paris-Sud.
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