| Physico-Chemical Characterization of γ-Amino n-Butyric Acid Nanoparticles. | |
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MedLine Citation:
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PMID: 21628904 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This work deals with the preparation and characterization of high-purity nanoparticles of γ-amino n-butyric acid (GABA) in order to enhance the efficiency of this drug. A sublimation procedure at low pressure was applied to GABA after improving the experimental parameters of this physical transformation. The elaboration of the molecule is solvent-free. The process does not change the chemical formula of the compound but modifies its physico-chemical characteristics. In this work, we present the experimental parameters for preparing monoclinic GABA nanoparticles. Their identification and physico-chemical properties were determined with a large number of investigations: Powder X-ray diffraction (PXRD), density and purity measurements, differential scanning calorimetry (DSC), thermo-gravimetric analysis (TGA), calorimetric measurements (ΔH(dissolution) and C(p)), thermally stimulated current (TSC), and electrochemical impedance. |
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Authors:
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Emma Dichi; Mehrez Sghaier; Bernard Fraisse; François Bonhomme |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 59 ISSN: 1347-5223 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 703-9 Citation Subset: IM |
Affiliation:
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Matériaux et Santé, EA 401 Faculté de Pharmacie, Université Paris-Sud. |
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