Document Detail

Physical work-induced oxidative stress is exacerbated in young cigarette smokers.
MedLine Citation:
PMID:  17365751     Owner:  NLM     Status:  MEDLINE    
Both cigarette smoking and strenuous physical work are associated with increased oxidative stress, which is implicated in the pathogenesis of cardiovascular disease. No study to date has measured oxidative stress in response to graded exercise in cigarette smokers. We compared oxidative stress biomarkers before and after strenuous exercise (Bruce treadmill protocol) in 14 cigarette smokers and 15 nonsmokers of similar age (24+/-6 years) and fitness status. Plasma protein carbonyls (PC), malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG) were measured pre- and postexercise. Smoking status (p<.01) and time (p<.01) effects were noted for PC with values higher for smokers than nonsmokers and increasing from pre- to postexercise (52% vs. 25%, respectively). The smoking statusxtime interaction for PC approached statistical significance (p=.07). The change in PC from pre- to postexercise was positively correlated with the number of cigarettes smoked per day (r=.5782, p=.03). A smoking statusxtime interaction was noted for MDA (p<.01), with values increasing 37% from pre- (0.6140+/-0.0708 micromol/L) to postexercise (0.8440+/-0.0687 micromol/L) for smokers and remaining relatively unchanged for nonsmokers (from 0.7664+/-0.0901 to 0.7419+/-0.0776 micromol/L). 8-OHdG was unaffected by smoking status (p=.43) or exercise (p=.40). These findings indicate that young cigarette smokers experience an exaggerated oxidative stress response to strenuous physical work, compared with nonsmokers of similar age. These results highlight yet another detrimental impact of cigarette smoking on human health. Future investigations should focus on older, more established smokers.
Richard J Bloomer; Andrea K Creasy; Webb A Smith
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco     Volume:  9     ISSN:  1462-2203     ISO Abbreviation:  Nicotine Tob. Res.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-03-16     Completed Date:  2007-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815751     Medline TA:  Nicotine Tob Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  IM    
Department of Health and Sport Sciences, The University of Memphis, TN 38152, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Deoxyguanosine / analogs & derivatives*,  blood
Exercise / physiology*
Malondialdehyde / blood*
Oxidative Stress / physiology*
Protein Carbonylation / physiology
Smoking / blood*,  metabolism
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 542-78-9/Malondialdehyde; 961-07-9/Deoxyguanosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Smoking practices, risk perception of smoking, and environmental tobacco smoke exposure among 6th-gr...
Next Document:  College student involvement in cigarette smoking: the role of psychosocial and behavioral protection...