| Physical structure characterization of theophylline in some acidic film-forming polymers. | |
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MedLine Citation:
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PMID: 10826118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The physical structure and drug-polymer interactions of theophylline in Eudragit L100, shellac, polyvinyl acetate phthalate (PVAP), cellulose acetate phthalate (CAP), hydroxypropylmethylcellulose acetate phthalate (HPMCP), and hydroxypropylmethylcellulose (HPMC) were studied. The drug-polymer films were prepared by casting and were characterized using powder X-ray diffractometry (PXRD), nuclear magnetic resonance (NMR) spectroscopy, and thin-layer chromatography (TLC). Theophylline was found to recrystallize in the modification II form in all kinds of polymers, which was the same as that recrystallized solely from the solvent system and the original powder. The PXRD and NMR results indicated a superficial drug-polymer interaction between theophylline and Eudragit L100, while there was no evidence of interaction for the others. No drug decomposition was observed by TLC for all drug-polymer mixtures. |
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Authors:
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N Sarisuta; M Kumpugdee; P Lawanprasert |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Drug development and industrial pharmacy Volume: 26 ISSN: 0363-9045 ISO Abbreviation: Drug Dev Ind Pharm Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-08-09 Completed Date: 2000-08-09 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 7802620 Medline TA: Drug Dev Ind Pharm Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 687-91 Citation Subset: IM |
Affiliation:
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Department of Manufacturing Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cellulose
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analogs & derivatives,
chemistry Chromatography, Thin Layer Crystallization Magnetic Resonance Spectroscopy Polyvinyls / chemistry Solvents / chemistry Theophylline / chemistry* Vasodilator Agents / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Polyvinyls; 0/Solvents; 0/Vasodilator Agents; 34481-48-6/polyvinylacetate phthalate polymer; 58-55-9/Theophylline; 9004-34-6/Cellulose; 9004-38-0/cellulose acetate phthalate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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