Document Detail

Physical structure characterization of theophylline in some acidic film-forming polymers.
MedLine Citation:
PMID:  10826118     Owner:  NLM     Status:  MEDLINE    
The physical structure and drug-polymer interactions of theophylline in Eudragit L100, shellac, polyvinyl acetate phthalate (PVAP), cellulose acetate phthalate (CAP), hydroxypropylmethylcellulose acetate phthalate (HPMCP), and hydroxypropylmethylcellulose (HPMC) were studied. The drug-polymer films were prepared by casting and were characterized using powder X-ray diffractometry (PXRD), nuclear magnetic resonance (NMR) spectroscopy, and thin-layer chromatography (TLC). Theophylline was found to recrystallize in the modification II form in all kinds of polymers, which was the same as that recrystallized solely from the solvent system and the original powder. The PXRD and NMR results indicated a superficial drug-polymer interaction between theophylline and Eudragit L100, while there was no evidence of interaction for the others. No drug decomposition was observed by TLC for all drug-polymer mixtures.
N Sarisuta; M Kumpugdee; P Lawanprasert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  26     ISSN:  0363-9045     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-09     Completed Date:  2000-08-09     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  687-91     Citation Subset:  IM    
Department of Manufacturing Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Cellulose / analogs & derivatives,  chemistry
Chromatography, Thin Layer
Magnetic Resonance Spectroscopy
Polyvinyls / chemistry
Solvents / chemistry
Theophylline / chemistry*
Vasodilator Agents / chemistry
Reg. No./Substance:
0/Polyvinyls; 0/Solvents; 0/Vasodilator Agents; 34481-48-6/polyvinylacetate phthalate polymer; 58-55-9/Theophylline; 9004-34-6/Cellulose; 9004-38-0/cellulose acetate phthalate

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