Document Detail


Physical stress and catecholamine release.
MedLine Citation:
PMID:  3327495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In both health and disease, noradrenaline and adrenaline concentrations in plasma increase with intensity and duration of exercise (Figure 1). These changes are only to a minor extent due to decreased catecholamine clearance (Figure 2). The increase in sympathoadrenal activity during exercise is primarily elicited by feed-forward stimulation from motor centres in the brain (Figure 3, Table 1), and by afferent impulses from working muscles (Figure 4). During continued exercise, changes in internal milieu may enhance the catecholamine response. Of particular interest from a metabolic point of view is the fact that during exercise a decrease in plasma glucose causes a relatively large increase in plasma adrenaline (Figure 5). Sympathoadrenal activity is of major importance for exercise capacity. By depressing insulin secretion, as well as by direct effects on target tissues, sympathoadrenal activity enhances mobilization of glycogen as well as triglyceride from both extra- and intramuscular depots. After training, noradrenaline responses to given absolute work loads are reduced, while responses to given relative loads, i.e. work load in percent of individual work capacity, VO2/VO2max%, are unchanged. Prolonged endurance training may increase the size and secretory capacity of the adrenal medulla (Figure 7, Table 2), an adaptation which may improve exercise capacity. Differences in catecholamine levels cannot explain the fact that physically-active individuals have a lower cardiac mortality than inactive ones.
Authors:
M Kjaer; N H Secher; H Galbo
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Baillière's clinical endocrinology and metabolism     Volume:  1     ISSN:  0950-351X     ISO Abbreviation:  Baillieres Clin. Endocrinol. Metab.     Publication Date:  1987 May 
Date Detail:
Created Date:  1988-04-08     Completed Date:  1988-04-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8704785     Medline TA:  Baillieres Clin Endocrinol Metab     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  279-98     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Catecholamines / secretion*
Energy Metabolism
Humans
Physical Exertion*
Chemical
Reg. No./Substance:
0/Catecholamines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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