Document Detail


Physical inactivity and cardiovascular risk: baseline observations from men and premenopausal women.
MedLine Citation:
PMID:  20333763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Physical activity or exercise is a proven deterrent of cardiovascular (CV) diseases. PURPOSE: In this study, we examined the relationships between baseline values of parameters related to physical activity and known markers of CV disease, including markers of oxidative stress. METHODS: A total of 455 healthy men and women between the ages of 18 and 50 were recruited to participate in the study. Levels of lipids/lipoproteins and markers of oxidative stress and inflammation were measured along with the VO(2) and duration time spent on treadmill. RESULTS: Women, in general, had a significantly (P<0.0001) higher plasma high density lipoprotein (1.51+/-0.30 mmol/l), decreased (P<0.0001) low density lipoprotein (LDL) (2.75+/-0.66 mmol/l), and decreased (P<0.0001) triglycerides levels (2.09+/-0.85 mmol/l), compared with males (1.21+/-0.23 mmol/l, 2.92+/-0.81 mmol/l, and 3.02+/-1.34 mmol/l, respectively). There was a direct correlation between the levels of plasma LDL and the levels oxidized LDL levels (P<0.0001) in both men and women. Despite a better antiatherogenic lipid profile, the levels of C-reactive protein in women were significantly (P<0.0001) elevated (3.78+/-3.66 ng/ml) as compared with those in men (1.82+/-2.37 ng/ml). CONCLUSION: These results suggest intrinsic sex differences between men and women in relation to atherogenic risk.
Authors:
Mahdi Garelnabi; Emir Veledar; Jerome Abramson; Jill White-Welkley; Nalini Santanam; William Weintraub; Sampath Parthasarathy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of clinical laboratory analysis     Volume:  24     ISSN:  1098-2825     ISO Abbreviation:  J. Clin. Lab. Anal.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-06-22     Revised Date:  2010-09-30    
Medline Journal Info:
Nlm Unique ID:  8801384     Medline TA:  J Clin Lab Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  100-5     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
Affiliation:
Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts Lowell, Massuchusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers / blood
C-Reactive Protein / analysis
Cardiovascular Diseases / blood,  physiopathology*
Exercise Test
Female
Hemodynamics
Humans
Lipids / blood
Lipoproteins / blood
Male
Middle Aged
Motor Activity / physiology*
Oxidative Stress
Oxygen Consumption
Physical Fitness / physiology*
Premenopause / blood,  physiology*
Risk Factors
Sex Factors
Young Adult
Grant Support
ID/Acronym/Agency:
DK056353/DK/NIDDK NIH HHS; HL69038/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lipids; 0/Lipoproteins; 9007-41-4/C-Reactive Protein

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