Document Detail

Physical and geometrical modeling for image-based recovery of left ventricular deformation.
MedLine Citation:
PMID:  9785945     Owner:  NLM     Status:  MEDLINE    
Information about left ventricular (LV) mechanical performance is of critical importance in understanding the etiology of ischemic heart disease. Regional measurements derived from non-invasive imaging to assist in assessing this performance have been in use for decades, and certain parameters derived from these measurements often are useful clinically, as they correlate to some extent with gross physiological hypotheses. However, relatively little work has been done to date to carefully understand the relationship of regional myocardial injury to the local mechanical performance of the heart as derived from image data acquired non-invasively for a particular patient in 3 spatial dimensions over time. This paper describes efforts to take advantage of recent developments in 3D non-invasive imaging and biomechanical modeling to design an integrated computational platform capable of assembling a variety of displacement and velocity data derived from each image frame to deform a volumetric model representation of a portion of the myocardium. A brief description of the reasoning behind this strategy an overview of the approach and some initial results are described.
J Duncan; P Shi; T Constable; A Sinusas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in biophysics and molecular biology     Volume:  69     ISSN:  0079-6107     ISO Abbreviation:  Prog. Biophys. Mol. Biol.     Publication Date:  1998  
Date Detail:
Created Date:  1998-11-16     Completed Date:  1998-11-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0401233     Medline TA:  Prog Biophys Mol Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  333-51     Citation Subset:  IM    
Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA.
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MeSH Terms
Heart / anatomy & histology*,  physiology*,  physiopathology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Models, Cardiovascular*
Myocardial Ischemia / etiology,  physiopathology*
Ventricular Dysfunction, Left / physiopathology*
Ventricular Function, Left / physiology*

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