Document Detail


Physical and genetic mapping of novel microsatellite polymorphisms on human chromosome 19.
MedLine Citation:
PMID:  8921379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe here the identification of 11 novel microsatellite polymorphisms on human chromosome 19. These dinucleotide repeat polymorphisms were detected in chromosome 19-specific cosmids that were physically mapped by fluorescence in situ hybridization. For each repeat, flanking oligonucleotide primers were synthesized and the polymerase chain reaction assay was performed on a panel of 100 unrelated individuals to determine the heterozygosity and allele frequencies. To characterize these markers further, genetic and radiation hybrid maps were constructed. These microsatellite polymorphisms will be valuable in further linkage analysis of inherited diseases on chromosome 19p.
Authors:
G B Collin; A Münch; J L Mu; J K Naggert; A S Olsen; P M Nishina
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  37     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-24     Completed Date:  1997-02-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  IM    
Affiliation:
Jackson Laboratory, Bar Harbor, Maine 04609-1500, USA.
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human, Pair 19*
DNA, Satellite / genetics*
Genetic Markers
Haplotypes
Humans
In Situ Hybridization, Fluorescence
Linkage (Genetics)
Polymorphism, Genetic*
Recombination, Genetic
Grant Support
ID/Acronym/Agency:
HL-48719/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Satellite; 0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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