Document Detail


Physical and genetic mapping of a novel chromosome 19 ERCC1 marker showing close linkage with myotonic dystrophy.
MedLine Citation:
PMID:  1674498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent genetic linkage analyses have mapped the myotonic dystrophy locus to the region of 19q13.2-13.3 lying distal to the gene for creatine kinase subunit M (CKM). The human excision repair gene ERCC1 has also been mapped to this region of chromosome 19. A novel polymorphic DNA marker, pEO.8, has been isolated from a chromosome 19 ERCC1-containing cosmid that maps to a 300-kb NotI fragment encompassing both CKM and ERCC1. Genetic linkage analysis reveals close linkage between pEO.8 and myotonic dystrophy (DM) (zmax = 19.3, theta max = 0.01). Analysis of two key recombinant events suggests a mapping of DM distal to pEO.8 and CKM.
Authors:
G Shutler; A E MacKenzie; H Brunner; B Wieringa; P de Jong; F P Lohman; S Leblond; J Bailly; R G Korneluk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  9     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-06-25     Completed Date:  1991-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  500-4     Citation Subset:  IM    
Affiliation:
Division of Genetic, Children's Hospital of Eastern Ontario, Ottawa, Canada.
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MeSH Terms
Descriptor/Qualifier:
Blotting, Southern
Canada
Chromosome Mapping
Chromosomes, Human, Pair 19*
Creatine Kinase / genetics
DNA Probes
DNA Repair / genetics*
Genetic Markers / genetics*
Humans
Linkage (Genetics)
Myotonic Dystrophy / genetics*
Netherlands
Pedigree
Polymorphism, Restriction Fragment Length
Recombination, Genetic
Chemical
Reg. No./Substance:
0/DNA Probes; 0/Genetic Markers; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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