Document Detail


Physical forces and non linear dynamics mould fractal cell shape. Quantitative morphological parameters and cell phenotype.
MedLine Citation:
PMID:  23275300     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cell shape is mainly determined by biophysical constraints, interacting according to non-linear dynamics upon the basic units provided by the genome. In turn, the specific configuration a cell acquires plays a fundamental, permissive role in modulating gene expression and many other complex biological functions. Cell shape is tightly connected to cell activity and can be considered the most critical determinant of cell function. As a consequence, measurable parameters describing shape could be considered as 'omics' descriptors of the specific level of observation represented by the cell-stroma system. Such an approach promises to formalize some of the underlying basic mechanisms and, ultimately, provide a holistic understanding of the biological processes.
Authors:
M Bizzarri; A Pasqualato; A Cucina; V Pasta
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histology and histopathology     Volume:  28     ISSN:  1699-5848     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-12-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  155-74     Citation Subset:  IM    
Affiliation:
Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy. mariano.bizzarri@uniroma1.it.
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