Document Detail

Physical fitness and insulin sensitivity in human subjects with a low insulin response to glucose.
MedLine Citation:
PMID:  7924163     Owner:  NLM     Status:  MEDLINE    
1. We have assessed insulin secretion, insulin sensitivity, exercise capacity and muscle fibre composition in healthy men with a low insulin response to glucose (low insulin responders and endurance-trained subjects) and in healthy men with a normally high insulin response. Low insulin responders have been considered as prediabetic subjects. 2. During glucose infusion, low insulin responders and endurance-trained subjects had acute-phase (0-10 min) insulin responses that were 26% (P < 0.001) and 31% (P < 0.001), and C-peptide responses that were 35% (P < 0.001) and 42% (P < 0.01), respectively of the responses in high insulin responders. Also, the late-phase (10-60 min) insulin and C-peptide responses were lower in low insulin responders and endurance-trained subjects. Endurance-trained subjects, compared with high and low insulin responders, had higher insulin sensitivity (blood glucose concentration during a somatostatin-insulin-glucose infusion test 3.6 +/- 0.4 versus 6.3 +/- 0.6 mmol/l in high insulin responders, P < 0.01, and 5.5 +/- 0.4 mmol/l in low insulin responders, P < 0.01), exercise capacity (4.2 +/- 0.2 versus 3.0 +/- 0.2 W/kg body weight, P < 0.001, and 2.8 +/- 0.1 W/kg body weight, P < 0.001) and a higher percentage of slow-twitch fibres (58.2 +/- 5.2 versus 38.5 +/- 3.5%, P < 0.01 and 40.9 +/- 3.0%, P < 0.001). 3. In conclusion, we demonstrate that low insulin responders exhibited decreased insulin and C-peptide responses to glucose, despite normal insulin sensitivity and exercise capacity.(ABSTRACT TRUNCATED AT 250 WORDS)
J Pigon; J Karlsson; C G Ostenson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  87     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-10-31     Completed Date:  1994-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  187-92     Citation Subset:  IM    
Department of Endocrinology, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
C-Peptide / secretion
Glucose / diagnostic use*
Glucose Tolerance Test
Insulin / diagnostic use,  secretion*
Insulin Resistance / physiology*
Muscles / metabolism
Physical Endurance / physiology
Physical Fitness / physiology*
Somatostatin / diagnostic use
Reg. No./Substance:
0/C-Peptide; 11061-68-0/Insulin; 50-99-7/Glucose; 51110-01-1/Somatostatin

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