Document Detail

Physical exercise training and neurovascular unit in ischemic stroke.
MedLine Citation:
PMID:  24780769     Owner:  NLM     Status:  Publisher    
Physical exercise could exert neuroprotective effect in both clinical studies and animal experiments. A series of related studies have indicated that physical exercise could reduce the infarct volume, alleviate the neurological deficits, decrease the blood brain barrier dysfunction, promote the angiogenesis in cerebral vascular and increase the survival rate after ischemic stroke. In this review, we summarized the protective effects of physical exercise on neurovascular unit (NVU), including neurons, astrocytes, pericytes and extracellular matrix. Furthermore, it was demonstrated that exercise training could decrease the blood brain barrier dysfunction and promote the angiogenesis in cerebral vascular. An awareness of the exercise intervention benefits pre- and post stroke may lead more stroke patients and people with high risk factors to accept exercise therapy for the prevention and treatment of stroke.
Xiao Wang; Min Zhang; Rui Feng; Wen-Bin Li; Shi-Qing Ren; Jing Zhang; Feng Zhang
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Publication Detail:
Type:  REVIEW     Date:  2014-4-26
Journal Detail:
Title:  Neuroscience     Volume:  -     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
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