Document Detail

Physical exercise inducing electrophysiological changes in the atria: sympathetic-mediated effects?
MedLine Citation:
PMID:  6525876     Owner:  NLM     Status:  MEDLINE    
Rats were subjected to long-term physical exercise by swimming and their hearts were examined electrophysiologically in order to identify relevant factors as mechanisms of protection from rhythm disturbances. The role of catecholamines was also studied using a chronically applied beta-adrenergic blocking drug, Practolol, or a catecholamine depleting drug, Reserpine. The results were compared with those obtained in rats similarly injected but kept in sedentary life. Action potential duration was found to be prolonged in trained animals regardless of the drug employed. Trained animals showed increments in the myocardial mass. Prolongation of the action potential coincided with lower values for maximum follow frequencies. It is suggested that the effects elicited could protect the heart against rhythm disturbances. The sympathetic nervous system seemed to play no important role.
A Sánchez; A Cabrera-Santos; M García; C Nieto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cor et vasa     Volume:  26     ISSN:  0010-8650     ISO Abbreviation:  Cor Vasa     Publication Date:  1984  
Date Detail:
Created Date:  1985-04-05     Completed Date:  1985-04-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372614     Medline TA:  Cor Vasa     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  456-65     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / physiopathology*
Cardiac Volume / drug effects
Catecholamines / metabolism
Heart / innervation*
Heart Atria / physiopathology*
Heart Rate / drug effects
Myocardial Contraction / drug effects
Physical Exertion*
Practolol / pharmacology
Reserpine / pharmacology
Sympathetic Nervous System / physiopathology*
Water-Electrolyte Balance / drug effects
Reg. No./Substance:
0/Catecholamines; 50-55-5/Reserpine; 6673-35-4/Practolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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