Document Detail

Physical exercise in adolescence changes CB1 cannabinoid receptor expression in the rat brain.
MedLine Citation:
PMID:  20621146     Owner:  NLM     Status:  MEDLINE    
Accumulating evidence indicates that the endocannabinoid system plays an essential role in the development and maturation of the central nervous system. Studies also have demonstrated that neural systems that regulate behavioral responses can be influenced by exercise during development. Exercise and endogenous cannabinoid activity have independently been shown to regulate brain plasticity, hence demonstrating a promising field of the endocannabinoid-exercise interaction. In order to investigate whether physical exercise during development would promote changes the brain endocannabinoid system, we investigated the cannabinoid receptor type 1 (CB1) expression in the brain of rats trained during the adolescent period. The results showed that an aerobic exercise program performed during adolescence significantly reduced the CB1 receptor expression in the striatum and hippocampal formation. These findings suggest an important link between the endocannabinoid system and physical training in adolescence.
Sérgio Gomes da Silva; Bruno Henrique Silva Araujo; Ana Carolina Cossa; Fulvio Alexandre Scorza; Esper Abrão Cavalheiro; Maria da Graça Naffah-Mazzacoratti; Ricardo Mario Arida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-17
Journal Detail:
Title:  Neurochemistry international     Volume:  57     ISSN:  1872-9754     ISO Abbreviation:  Neurochem. Int.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  492-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Department of Physiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
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MeSH Terms
Aging / physiology
Blotting, Western
Body Weight / physiology
Brain / growth & development
Brain Chemistry / physiology*
Cerebral Cortex / anatomy & histology,  metabolism
Corpus Striatum / anatomy & histology,  metabolism
Hippocampus / anatomy & histology,  metabolism
Physical Conditioning, Animal / physiology*
Rats, Wistar
Receptor, Cannabinoid, CB1 / biosynthesis*
Reg. No./Substance:
0/Receptor, Cannabinoid, CB1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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