| Physical exercise in adolescence changes CB1 cannabinoid receptor expression in the rat brain. | |
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MedLine Citation:
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PMID: 20621146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Accumulating evidence indicates that the endocannabinoid system plays an essential role in the development and maturation of the central nervous system. Studies also have demonstrated that neural systems that regulate behavioral responses can be influenced by exercise during development. Exercise and endogenous cannabinoid activity have independently been shown to regulate brain plasticity, hence demonstrating a promising field of the endocannabinoid-exercise interaction. In order to investigate whether physical exercise during development would promote changes the brain endocannabinoid system, we investigated the cannabinoid receptor type 1 (CB1) expression in the brain of rats trained during the adolescent period. The results showed that an aerobic exercise program performed during adolescence significantly reduced the CB1 receptor expression in the striatum and hippocampal formation. These findings suggest an important link between the endocannabinoid system and physical training in adolescence. |
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Authors:
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Sérgio Gomes da Silva; Bruno Henrique Silva Araujo; Ana Carolina Cossa; Fulvio Alexandre Scorza; Esper Abrão Cavalheiro; Maria da Graça Naffah-Mazzacoratti; Ricardo Mario Arida |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-17 |
Journal Detail:
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Title: Neurochemistry international Volume: 57 ISSN: 1872-9754 ISO Abbreviation: Neurochem. Int. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006959 Medline TA: Neurochem Int Country: England |
Other Details:
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Languages: eng Pagination: 492-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Physiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. sergio.gomes@unifesp.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Animals Blotting, Western Body Weight / physiology Brain / growth & development Brain Chemistry / physiology* Cerebral Cortex / anatomy & histology, metabolism Corpus Striatum / anatomy & histology, metabolism Hippocampus / anatomy & histology, metabolism Immunohistochemistry Male Physical Conditioning, Animal / physiology* Rats Rats, Wistar Receptor, Cannabinoid, CB1 / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Cannabinoid, CB1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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