| Physical exercise improves properties of bone and its collagen network in growing and maturing mice. | |
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MedLine Citation:
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PMID: 19641838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study characterized bone structure, composition, and mechanical properties in growing male mice. The development of the collagen network during maturation was monitored, and the effect of voluntary physical exercise was investigated. We hypothesized that increased bone loading from exercise would increase the amount and improve the properties of the collagen network during growth and maturation. Half of the mice (total n = 168) had access to running wheels, while half were kept sedentary. Weight and running activity were recorded, and groups of mice were killed at 1, 2, 4, and 6 months of age. The collagen network was assessed by biochemical evaluation of collagen content and cross-links and by tensile testing of decalcified bone. Mineralized femur was analyzed with pQCT and three-point-bending and femoral neck-strength tests. After 6 months, the exercising mice had 10% lower body weight than the sedentary group. There was no difference in the amount of collagen or collagen cross-links, while tensile testing had higher breaking force and stiffness of the collagen network in runners after 4 months but not after 6 months. The bone mineral density and cross-sectional area were higher in the running group after 6 months. Runners also showed higher breaking force and stiffness of the diaphysis and the femoral neck at 2 and 6 months. The significant modulation of mechanical properties of the collagen network without any change in collagen content indicates that physical exercise improves properties of the collagen network in maturing bone. The improvement after exercise of the properties of mineralized bone appears to be more pronounced and long-lasting compared to the early improved properties of the collagen network. |
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Authors:
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Hanna Isaksson; Viivi Tolvanen; Mikko A J Finnilä; Jarkko Iivarinen; Juha Tuukkanen; Kari Seppänen; Jari P A Arokoski; Pieter A Brama; Jukka S Jurvelin; Heikki J Helminen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-30 |
Journal Detail:
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Title: Calcified tissue international Volume: 85 ISSN: 1432-0827 ISO Abbreviation: Calcif. Tissue Int. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-27 Completed Date: 2009-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905481 Medline TA: Calcif Tissue Int Country: United States |
Other Details:
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Languages: eng Pagination: 247-56 Citation Subset: IM |
Affiliation:
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Department of Physics, University of Kuopio, P.O. Box 1627, 70211, Kuopio, Finland. hanna.isaksson@uku.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology Animals Biomechanics Bone Density / physiology Bone Development / physiology* Bone and Bones / chemistry, cytology, metabolism* Collagen / metabolism* Diaphyses / metabolism Exercise Therapy / methods* Extracellular Matrix / metabolism Femur Neck / anatomy & histology, physiology Male Mice Mice, Inbred C57BL Organ Size / physiology Physical Conditioning, Animal / physiology* Physical Endurance / physiology Pliability Running / physiology Stress, Mechanical Tensile Strength Treatment Outcome Weight-Bearing / physiology |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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