Document Detail


Physical exercise improves motor and short-term social memory deficits in reserpinized rats.
MedLine Citation:
PMID:  19463920     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have shown that cognitive deficits precede the classical motor symptoms seen in Parkinson's disease (PD) and that physical exercise may exert beneficial effects on PD. We have recently verified that the monoamine-depleting drug reserpine - at doses that do not modify motor function - impairs memory processes in rats. Here, we evaluated the potential of physical exercise to improve cognitive and motor deficits induced by reserpine. Adult Wistar rats were assigned to six groups: (1) untrained-vehicle; (2) untrained-reserpine; (3) running wheel (RW)-vehicle; (4) RW-reserpine; (5) treadmill-vehicle; and (6) treadmill-reserpine. Exercise groups were given free nocturnal access to RW or continuous treadmill exercise (20-25 min/day) for 5 days/week over 4 weeks. The animals were injected subcutaneously with reserpine (1.0 or 5.0mg/kg) or vehicle 48 h after the end of physical program, and 24h later they were tested in a battery of behavioral paradigms. RW and treadmill improved the motor deficits induced by a high reserpine dose (5.0mg/kg), as evaluated in the rotarod and open-field tests. Moreover, untrained rats treated with a low reserpine dose (1.0mg/kg) presented short-term social memory deficits (without motor or olfactory disturbance) that were selectively improved by the exercise training. Our results reinforce the potential of low to moderate physical exercise as a useful tool in the prevention of motor and cognitive impairments associated to CNS monoaminergic depletion.
Authors:
Aderbal S Aguiar; Andréa L Araújo; Thaise R da-Cunha; Ana E Speck; Zuleide M Ignácio; Nelson De-Mello; Rui D S Prediger
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-20
Journal Detail:
Title:  Brain research bulletin     Volume:  79     ISSN:  1873-2747     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  452-7     Citation Subset:  IM    
Affiliation:
Laboratório Experimental de Doenças Neurodegenerativas, Departamento de Farmacologia, Universidade Federal de Santa Catarina (UFSC), 88049-900 Florianópolis, SC, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Discrimination (Psychology) / drug effects,  physiology
Dose-Response Relationship, Drug
Male
Memory Disorders / chemically induced,  therapy*
Motor Activity / drug effects,  physiology
Movement Disorders / therapy*
Olfactory Perception / drug effects,  physiology
Physical Conditioning, Animal*
Random Allocation
Rats
Rats, Wistar
Recognition (Psychology) / drug effects,  physiology
Reserpine
Social Perception*
Time Factors
Chemical
Reg. No./Substance:
50-55-5/Reserpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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