Document Detail

Physical exercise during the adolescent period of life increases hippocampal parvalbumin expression.
MedLine Citation:
PMID:  19168302     Owner:  NLM     Status:  MEDLINE    
In order to investigate whether physical exercise during development would promote changes the calcium-binding protein parvalbumin (PV) expression in the hippocampal formation, we performed an immunostaining study after an aerobic exercise program in rats during adolescent period of life. Wistar rats were submitted to daily exercise program in a treadmill between postnatal day 21 and 60. Running time and speed were gradually increased during the subsequent days until 18m/min for 60min. After the aerobic exercise program, animals of all groups were killed and PV immunostaining procedures were performed. The results showed significant increase of protein level in the hippocampal formation and PV-immunoreactive neurons in CA1 and CA2/CA3 regions of rats submitted to exercise when compared with control rats. This finding indicates that aerobic exercise program during adolescent period promotes neuroplastic changes in hippocampal formation.
S?rgio Gomes da Silva; Fl?via Don?; Maria Jos? da Silva Fernandes; Fulvio Alexandre Scorza; Esper Abr?o Cavalheiro; Ricardo Mario Arida
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-24
Journal Detail:
Title:  Brain & development     Volume:  32     ISSN:  1872-7131     ISO Abbreviation:  Brain Dev.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
Copyright Information:
2008 Elsevier B.V. All rights reserved.
Department of Physiology, Universidade Federal de S?o Paulo, Brazil.
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MeSH Terms
Adolescent / physiology*
Hippocampus / cytology,  physiology*
Neuronal Plasticity / physiology
Neurons / cytology,  metabolism
Parvalbumins / metabolism*
Physical Conditioning, Animal / physiology*
Rats, Wistar
Reg. No./Substance:

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