Document Detail

Physical exercise, aging, and mild cognitive impairment: a population-based study.
MedLine Citation:
PMID:  20065133     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Physical exercise is associated with decreased risk of dementia and Alzheimer disease.
OBJECTIVE: To investigate whether physical exercise is associated with decreased risk of mild cognitive impairment (MCI).
DESIGN: Population-based case-control study.
SETTING: The Mayo Clinic Study of Aging, an ongoing population-based cohort study in Olmsted County, Minnesota.
PARTICIPANTS: A total of 1324 subjects without dementia who completed a Physical Exercise Questionnaire.
MAIN OUTCOME MEASURES: An expert consensus panel classified each subject as having normal cognition or MCI based on published criteria.
RESULTS: We compared the frequency of physical exercise among 198 subjects with MCI with that among 1126 subjects with normal cognition and adjusted the analyses for age, sex, years of education, medical comorbidity, and depression. The odds ratios for any frequency of moderate exercise were 0.61 (95% confidence interval, 0.43-0.88; P = .008) for midlife (age range, 50-65 years) and 0.68 (95% confidence interval, 0.49-0.93; P = .02) for late life. The findings were consistent among men and women. Light exercise and vigorous exercise were not significantly associated with decreased risk of MCI.
CONCLUSION: In this population-based case-control study, any frequency of moderate exercise performed in midlife or late life was associated with a reduced odds of having MCI.
Yonas E Geda; Rosebud O Roberts; David S Knopman; Teresa J H Christianson; V Shane Pankratz; Robert J Ivnik; Bradley F Boeve; Eric G Tangalos; Ronald C Petersen; Walter A Rocca
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of neurology     Volume:  67     ISSN:  1538-3687     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-12     Completed Date:  2010-02-12     Revised Date:  2013-12-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  80-6     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Aging / physiology*,  psychology
Alzheimer Disease / prevention & control,  therapy*
Case-Control Studies
Cognition Disorders / diagnosis,  epidemiology*,  therapy*
Cohort Studies
Depressive Disorder / epidemiology,  therapy
Exercise Therapy / methods*
Middle Aged
Odds Ratio
Physical Fitness / physiology*
Risk Reduction Behavior
Sex Distribution
Treatment Outcome
Grant Support
K01 AG028573/AG/NIA NIH HHS; K01 AG028573-03/AG/NIA NIH HHS; K01 MH068351/MH/NIMH NIH HHS; K01 MH068351-07/MH/NIMH NIH HHS; P50 AG016574/AG/NIA NIH HHS; P50 AG016574/AG/NIA NIH HHS; P50 AG016574-10/AG/NIA NIH HHS; R01 AR030582/AR/NIAMS NIH HHS; R01 AR030582-43/AR/NIAMS NIH HHS; R01 NS033978/NS/NINDS NIH HHS; R01 NS033978-10/NS/NINDS NIH HHS; U01 AG006786/AG/NIA NIH HHS; U01 AG006786/AG/NIA NIH HHS; U01 AG006786-23/AG/NIA NIH HHS

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