Document Detail


Physical exercise activates the poly(ADP-ribosyl)ation system in rat testes.
MedLine Citation:
PMID:  20846480     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Given the high sensitivity of the male reproductive system to oxidative stress and to temperature changes, the amount of germ cell apoptosis and the activation of the poly(ADP-ribosyl)ation system (a very sensitive index of genotoxic stress) were evaluated in the testicular tissue of adult rats which underwent a 10-wk treadmill training, according to either a mild or a strong protocol; rats were sacrificed 24 h after the last training session or after a single bout of an additional stressing exercise (30 min of swimming). Controls were untrained rats (one resting group and one group with acute exercise). Both training and acute exercise increased marginally germ cell apoptotic indexes (caspase-induced poly(ADP-ribose) polymerase fragmentation and TUNEL-positive cells), while the activity of poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase enzymes was affected in a way that suggests that acute exercise is associated with reversible genotoxic stress, and that training induces adaptive responses, as demonstrated by the activation of poly(ADP-ribose) polymerase system without subsequent increase in apoptosis.
Authors:
M R Faraone-Mennella; M Marini; A Ferone; O Cacace; A Liguoro; V Margonato; B Farina; A Veicsteinas
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biological regulators and homeostatic agents     Volume:  24     ISSN:  0393-974X     ISO Abbreviation:  J. Biol. Regul. Homeost. Agents     Publication Date:    2010 Jul-Sep
Date Detail:
Created Date:  2010-09-17     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809253     Medline TA:  J Biol Regul Homeost Agents     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  325-33     Citation Subset:  IM    
Affiliation:
Department of Structural and Functional Biology, University of Naples, Federico II, Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Male
Physical Conditioning, Animal*
Poly(ADP-ribose) Polymerases / metabolism*
Rats
Rats, Sprague-Dawley
Testis / metabolism*,  pathology
Thyroid Hormones / blood
Chemical
Reg. No./Substance:
0/Thyroid Hormones; EC 2.4.2.30/Poly(ADP-ribose) Polymerases

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