Document Detail

Physical determinants of line pressures during apheresis.
MedLine Citation:
PMID:  10623357     Owner:  NLM     Status:  MEDLINE    
Line pressure changes are inherent to apheresis procedures, although little work has been done to determine their physical basis. We developed a mathematical model in which fluid pressure within apheresis tubing is primarily dependent upon viscosity and hematocrit (HCT). Return line flow rates and pressures during plasma collections for peripheral blood stem cell (PBSC) harvest and during plasma exchange procedures using the COBE Spectra were recorded and used to model return line pressures. Pressure estimates were similar to measured values for both PBSC plasma collection (r2 = 0.70) and plasma exchange (r2 = 0.86). HCT and viscosity thus appear to be primary physical determinants that underlie these pressure changes.
T P Nifong; G S Gerhard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transfusion science     Volume:  20     ISSN:  0955-3886     ISO Abbreviation:  Transfus Sci     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-12-14     Completed Date:  1999-12-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9001514     Medline TA:  Transfus Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  167-73     Citation Subset:  T    
Department of Pathology, Penn State College of Medicine, Hershey 17033, USA.
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MeSH Terms
Blood Component Removal / instrumentation*
Models, Theoretical

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