Document Detail


Physical dependence following prolonged ethanol or t-butanol administration to rats.
MedLine Citation:
PMID:  571606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats were fed on liquid diets containing ethanol or t-butanol. On removal of either alcohol from the diet after 4-20 days, withdrawal reactions were observed. The range of withdrawal signs produced by the two alcohols were identical although the time course of the withdrawal reactions differed. Administration of one alcohol prevented the appearance of a withdrawal reaction in rats dependent on the other alcohol. Depletion of brain noradrenaline and dopamine did not prevent the development of physical dependence on either alcohol. Thus, neither aldehyde formation nor brain catecholamines appear to be involved in the development of physical dependence on these alcohols.
Authors:
J M Wood; R Laverty
Related Documents :
2573096 - Effects of prenatal alcohol on gamma-glutamyl transpeptidase in various brain regions.
15380836 - Vitamin e protects against alcohol-induced cell loss and oxidative stress in the neonat...
10417056 - Role of kupffer cells in the ethanol-induced oxidative stress in the liver.
23253046 - Amelioration of alzheimer's disease by neuroprotective effect of sulforaphane in animal...
574816 - Diurnal variation in uterine estrogen receptors in immature female rats--inhibition by ...
7272586 - Atropine and micturition responses by rats with intact and partially innervated bladder.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  10     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-07-25     Completed Date:  1979-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alcoholism / etiology*
Animals
Brain Chemistry / drug effects
Butanols / blood,  pharmacology*
Catecholamines / metabolism
Ethanol / blood
Humans
Hydroxydopamines / pharmacology
Male
Rats
Substance Withdrawal Syndrome / physiopathology
Substance-Related Disorders / etiology*
Time Factors
Chemical
Reg. No./Substance:
0/Butanols; 0/Catecholamines; 0/Hydroxydopamines; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Non-effect of Massachusetts cement kiln dust upon the food intake, body weight, or activity of femal...
Next Document:  Videotaping: the evaluation of stereotypic effects of antiparkinsonian agents.