Document Detail

Physical dependence following prolonged ethanol or t-butanol administration to rats.
MedLine Citation:
PMID:  571606     Owner:  NLM     Status:  MEDLINE    
Rats were fed on liquid diets containing ethanol or t-butanol. On removal of either alcohol from the diet after 4-20 days, withdrawal reactions were observed. The range of withdrawal signs produced by the two alcohols were identical although the time course of the withdrawal reactions differed. Administration of one alcohol prevented the appearance of a withdrawal reaction in rats dependent on the other alcohol. Depletion of brain noradrenaline and dopamine did not prevent the development of physical dependence on either alcohol. Thus, neither aldehyde formation nor brain catecholamines appear to be involved in the development of physical dependence on these alcohols.
J M Wood; R Laverty
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  10     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-07-25     Completed Date:  1979-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
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MeSH Terms
Alcoholism / etiology*
Brain Chemistry / drug effects
Butanols / blood,  pharmacology*
Catecholamines / metabolism
Ethanol / blood
Hydroxydopamines / pharmacology
Substance Withdrawal Syndrome / physiopathology
Substance-Related Disorders / etiology*
Time Factors
Reg. No./Substance:
0/Butanols; 0/Catecholamines; 0/Hydroxydopamines; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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