| Physical deconditioning may be a mechanism for the skeletal muscle energy phosphate metabolism abnormalities in chronic heart failure. | |
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MedLine Citation:
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PMID: 8604638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of our study was to investigate the contribution of physical deconditioning in skeletal muscle metabolic abnormalities in patients with chronic heart failure (CHF). Phosphate metabolism was studied in the leg muscle at rest and during exercise by using phosphate 31 nuclear magnetic resonance spectroscopy in a group of 14 patients with New York Heart Association class II and III CHF and left ventricular ejection fraction <40% and in two groups of age-matched healthy volunteers: one group of 7 sedentary and another of 7 trained subjects. Phosphocreatine depletion rate, intracellular pH, and adenosine diphosphate levels in the muscle during exercise were not statistically different in the CHF patients and in the sedentary healthy subjects, but both groups were statistically different from the trained healthy subjects, who had slower phosphocreatine depletion rates, as well as less intracellular acidosis and lower adenosine diphosphate levels during exercise (p = 0.02; analysis of variance). Our results suggest that metabolic changes occurring in the skeletal muscle of patients with CHF may contribute to the limitation of exercise capacity and are most likely to be a consequence of physical deconditioning because they are very similar to what is observed in sedentary and otherwise healthy subjects as compared with trained subjects. |
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Authors:
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Z Chati; F Zannad; C Jeandel; B Lherbier; Escanye J-M; J Robert; E Aliot |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American heart journal Volume: 131 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-05-15 Completed Date: 1996-05-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 560-6 Citation Subset: AIM; IM; S |
Affiliation:
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Service de Cardiologie, Hopital Central, Nancy, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiovascular Deconditioning* Exercise Test Female Heart Failure / metabolism* Humans Hydrogen-Ion Concentration Magnetic Resonance Spectroscopy / instrumentation, methods Male Middle Aged Muscle, Skeletal / metabolism* Phosphates / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Phosphates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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