| Physical and clinicopathologic findings in foals derived by use of somatic cell nuclear transfer: 14 cases (2004-2008). | |
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MedLine Citation:
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PMID: 20433399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe the health status of foals derived by use of somatic cell nuclear transfer (NT) at a university laboratory. DESIGN: Retrospective case series. ANIMALS: 14 live-born NT-derived foals. PROCEDURES: Medical records from 2004 through 2008 were evaluated to identify all pregnancies resulting in live-born NT-derived foals. Information obtained included gestation length, birth weight, foaling complications, gross abnormalities of the fetal membranes, appearance of the umbilicus, mentation of the foal, limb deformities, and any other abnormalities detected in the neonatal period. Clinicopathologic data were also evaluated when available. Records of 4 recipient mares during gestation were included. RESULTS: Six foals were clinically normal for all evaluated variables. The most common abnormalities detected in the remaining 8 foals included maladjustment, enlarged umbilical remnant, and angular deformity of the forelimbs. Two foals died within 7 days after parturition; in the remaining foals, these conditions all resolved with medical or surgical management. Large offspring syndrome and gross abnormalities of the fetal membranes were not detected. The 12 surviving foals remained healthy. CONCLUSIONS AND CLINICAL RELEVANCE: Associated problems of calves resulting from use of NT have been reported, but there are few data on the outcome of foals resulting from adult somatic cell NT in horses. Although this population of foals had a lower perinatal mortality rate than has been reported for NT-derived calves, some NT-derived foals required aggressive supportive care. Birth of foals derived from NT should take place at a center equipped to handle critical care of neonates. |
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Authors:
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Aime K Johnson; Stuart C Clark-Price; Young-Ho Choi; David L Hartman; Katrin Hinrichs |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Veterinary Medical Association Volume: 236 ISSN: 0003-1488 ISO Abbreviation: J. Am. Vet. Med. Assoc. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-05-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503067 Medline TA: J Am Vet Med Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 983-90 Citation Subset: IM |
Affiliation:
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Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA. akj0001@auburn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Cloning, Organism / veterinary* Embryo Transfer / veterinary Embryonic Development Female Horses* Longevity Nuclear Transfer Techniques / veterinary* Pregnancy Pregnancy Complications / veterinary Pregnancy Outcome Reproductive Techniques, Assisted / veterinary* Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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