| Physical chemistry of nucleic acids. | |
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MedLine Citation:
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PMID: 11972000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Watson-Crick double helix of DNA was first revealed in 1953. Since then a wide range of physical chemical methods have been applied to DNA and to its more versatile relative RNA to determine their structures and functions. My major goal is to predict the folded structure of any RNA from its sequence. We have used bulk and single-molecule measurements of thermodynamics and kinetics, plus various spectroscopic methods (UV absorption, optical rotation, circular dichroism, circular intensity differential scattering, fluorescence, NMR) to approach this goal. |
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Authors:
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Ignacio Tinoco |
Publication Detail:
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Type: Biography; Historical Article; Journal Article Date: 2001-10-04 |
Journal Detail:
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Title: Annual review of physical chemistry Volume: 53 ISSN: 0066-426X ISO Abbreviation: Annu Rev Phys Chem Publication Date: 2002 |
Date Detail:
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Created Date: 2002-04-24 Completed Date: 2002-07-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 15040080R Medline TA: Annu Rev Phys Chem Country: United States |
Other Details:
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Languages: eng Pagination: 1-15 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of California and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720-1460, USA. Intinoco@lbl.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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DNA
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chemistry,
history* History, 20th Century Kinetics Nucleic Acid Conformation RNA / chemistry, history* Thermodynamics United States |
| Chemical | |
Reg. No./Substance:
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63231-63-0/RNA; 9007-49-2/DNA |
| Personal Name Subject | |
Personal Name Subject:
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I Tinoco |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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