Document Detail


Physical chemistry of nucleic acids.
MedLine Citation:
PMID:  11972000     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Watson-Crick double helix of DNA was first revealed in 1953. Since then a wide range of physical chemical methods have been applied to DNA and to its more versatile relative RNA to determine their structures and functions. My major goal is to predict the folded structure of any RNA from its sequence. We have used bulk and single-molecule measurements of thermodynamics and kinetics, plus various spectroscopic methods (UV absorption, optical rotation, circular dichroism, circular intensity differential scattering, fluorescence, NMR) to approach this goal.
Authors:
Ignacio Tinoco
Publication Detail:
Type:  Biography; Historical Article; Journal Article     Date:  2001-10-04
Journal Detail:
Title:  Annual review of physical chemistry     Volume:  53     ISSN:  0066-426X     ISO Abbreviation:  Annu Rev Phys Chem     Publication Date:  2002  
Date Detail:
Created Date:  2002-04-24     Completed Date:  2002-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15040080R     Medline TA:  Annu Rev Phys Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-15     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of California and Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720-1460, USA. Intinoco@lbl.gov
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MeSH Terms
Descriptor/Qualifier:
DNA / chemistry,  history*
History, 20th Century
Kinetics
Nucleic Acid Conformation
RNA / chemistry,  history*
Thermodynamics
United States
Chemical
Reg. No./Substance:
63231-63-0/RNA; 9007-49-2/DNA
Personal Name Subject
Personal Name Subject:
I Tinoco

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