Document Detail

Physical characteristics and gas composition of nasal air affect nasal nitric oxide release.
MedLine Citation:
PMID:  9926992     Owner:  NLM     Status:  MEDLINE    
We studied modulation of release of nitric oxide (NO) into nasal passages by physical characteristics (airflow, temperature, humidity) or gases (oxygen, carbon dioxide) in nasal air of humans. Each characteristic or gas in nasal air was changed during voluntary soft palate elevation (to isolate nasal passages). Increasing airflow through the nose caused incremental increases in NO release from 211+/-23 nl/(min x m(-2)) at 1 L/min to 312+/-40 nl/(min x m(-2)) at 22 L/min (P<0.001, n = 6). Decreased humidity (dry airflow, 1-22 L/min) reduced NO release only at the highest airflow rate. Changing temperature (range 46 to 0 degrees C) had no effect on NO release. Hypoxia (below 4% O2) rapidly and reversibly decreased NO release (200+/-40 nl/(min x m(-2)) at 21% O2 versus 99+/-17 nl/(min x m(-2)) at 0% O2 for 3 min, (P<0.001, n = 5). Carbon dioxide (5%) reduced NO release slightly. We conclude that airflow, reduced humidity, carbon dioxide concentration, and oxygen concentration modulate NO release into nasal passages.
G D Giraud; B Nejadnik; B Kimberly; W E Holden
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  114     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-04-21     Completed Date:  1999-04-21     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  285-96     Citation Subset:  IM    
Medical Service, Portland Veterans Administration Medical Center, OR 97201, USA.
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MeSH Terms
Carbon Dioxide / pharmacology
Middle Aged
Nasal Cavity / chemistry*,  metabolism
Nitric Oxide / metabolism*
Oxygen / metabolism,  pharmacology
Palate, Soft / metabolism
Reg. No./Substance:
10102-43-9/Nitric Oxide; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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