Document Detail

Physical activity, stress reduction, and mood: insight into immunological mechanisms.
MedLine Citation:
PMID:  22933142     Owner:  NLM     Status:  MEDLINE    
Psychosocial factors, such as chronic mental stress and mood, are recognized as an important predictor of longevity and wellbeing. In particular, depression is independently associated with cardiovascular disease and all-cause mortality, and is often comorbid with chronic diseases that can worsen their associated health outcomes. Regular exercise is thought to be associated with stress reduction and better mood, which may partly mediate associations between depression, stress, and health outcomes. The underlying mechanisms for the positive effects of exercise on wellbeing remain poorly understood. In this overview we examine epidemiological evidence for an association between physical activity and mental health. We then describe the exercise withdrawal paradigm as an experimental protocol to study mechanisms linking exercise, mood, and stress. In particular we will discuss the potential role of the inflammatory response as a central mechanism.
Mark Hamer; Romano Endrighi; Lydia Poole
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  934     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-30     Completed Date:  2013-01-07     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  89-102     Citation Subset:  IM    
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MeSH Terms
Affect* / physiology
Depression / epidemiology*,  immunology
Exercise* / physiology,  psychology
Inflammation / epidemiology,  immunology
Mental Health
Mood Disorders / epidemiology*,  immunology
Stress, Psychological / immunology*,  psychology
Grant Support
FS/09/049/27874//British Heart Foundation; RG/10/005/28296//British Heart Foundation; //British Heart Foundation

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