Document Detail

Physical activity reduces systemic blood pressure and improves early markers of atherosclerosis in pre-pubertal obese children.
MedLine Citation:
PMID:  20082930     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to determine the effects of physical activity on systemic blood pressure (BP) and early markers of atherosclerosis in pre-pubertal obese children. BACKGROUND: Hypertension and endothelial dysfunction are premature complications of obesity. METHODS: We performed a 3-month randomized controlled trial with a modified crossover design: 44 pre-pubertal obese children (age 8.9 + or - 1.5 years) were randomly assigned (1:1) to an exercise (n = 22) or a control group (n = 22). We recruited 22 lean children (age 8.5 + or - 1.5 years) for baseline comparison. The exercise group trained 60 min 3 times/week during 3 months, whereas control subjects remained relatively inactive. Then, both groups trained twice/week during 3 months. We assessed changes at 3 and 6 months in office and 24-h BP, arterial intima-media thickness (IMT) and stiffness, endothelial function (flow-mediated dilation), body mass index (BMI), body fat, cardiorespiratory fitness (maximal oxygen consumption [VO(2)max]), physical activity, and biological markers. RESULTS: Obese children had higher BP, arterial stiffness, body weight, BMI, abdominal fat, insulin resistance indexes, and C-reactive protein levels, and lower flow-mediated dilation, VO(2)max, physical activity, and high-density lipoprotein cholesterol levels than lean subjects. At 3 months, we observed significant changes in 24-h systolic BP (exercise -6.9 + or - 13.5 mm Hg vs. control 3.8 + or - 7.9 mm Hg, -0.8 + or - 1.5 standard deviation score [SDS] vs. 0.4 + or - 0.8 SDS), diastolic BP (-0.5 + or - 1.0 SDS vs. 0 + or - 1.4 SDS), hypertension rate (-12% vs. -1%), office BP, BMI z-score, abdominal fat, and VO(2)max. At 6 months, change differences in arterial stiffness and IMT were significant. CONCLUSIONS: A regular physical activity program reduces BP, arterial stiffness, and abdominal fat; increases cardiorespiratory fitness; and delays arterial wall remodeling in pre-pubertal obese children. (Effects of Aerobic Exercise Training on Arterial Function and Insulin Resistance Syndrome in Obese Children: A Randomized Controlled Trial; NCT00801645).
Nathalie J Farpour-Lambert; Yacine Aggoun; Laetitia M Marchand; Xavier E Martin; Fran?ois R Herrmann; Maurice Beghetti
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  54     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-19     Completed Date:  2010-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2396-406     Citation Subset:  AIM; IM    
Pediatric Cardiology Unit, Department of Child and Adolescent, University Hospitals of Geneva, 6 rue Willy-Donze, 1211 Geneva 14, Switzerland.
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MeSH Terms
Atherosclerosis / blood*,  physiopathology*
Biological Markers / blood
Body Fat Distribution
Body Height / physiology
Body Mass Index
Body Weight / physiology
Carotid Artery, Common / ultrasonography
Cholesterol, HDL / blood
Cross-Over Studies
Endothelium, Vascular / physiology,  ultrasonography
Exercise / physiology*
Exercise Tolerance / physiology
Hypertension / physiopathology,  therapy*
Insulin Resistance / physiology
Obesity / physiopathology,  therapy*
Oxygen Consumption / physiology
Physical Fitness / physiology
Puberty / physiology
Regional Blood Flow / physiology
Tunica Intima / ultrasonography
Tunica Media / ultrasonography
Vasodilation / physiology
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, HDL
Comment In:
J Am Coll Cardiol. 2009 Dec 15;54(25):2407-8   [PMID:  20082931 ]

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